Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes

Inclusion Criteria: - For Japan only: Male or female, age above or equal to 20 years at the
time of signing inform consent - Subjects diagnosed with type 2 diabetes and treated with
diet and exercise for at least 30 days before screening - HbA1c 7.0 - 10.0 % (53 - 86
mmol/mol) (both inclusive) Exclusion Criteria: - Female who is pregnant, breast-feeding or
intends to become pregnant or is of child-bearing potential and not using adequate
contraceptive method (adequate contraceptive measures as required by local regulation or
practice) throughout the trial including the 5 week follow-up period. United Kingdom:
Adequate contraceptive measures are defined as established use of oral, injected or
implanted hormonal methods of contraception, placement of an intrauterine device or
intrauterine system, barrier methods of contraception (condom or occlusive cap with
spermicidal foam/gel/film/cream/suppository), male sterilisation (where partner is sole
partner of subject), or true abstinence (when in line with preferred and usual lifestyle) -
Any chronic disorder or severe disease which, in the opinion of the investigator, might
jeopardise subject's safety or compliance with the protocol - Treatment with any glucose
lowering agent(s) in a period of 90 days prior to screening. An exception is short-term
treatment (no longer than 7 days in total) with insulin in connection with inter-current
illness - History of chronic or idiopathic acute pancreatitis - Screening calcitonin value
above or equal to 50 ng/L (pg/mL) - Personal or family history of medullary thyroid
carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) - Impaired renal function
defined as eGFR (estimated glomerular filtration rate ) below 30 mL/min/1.73 m^2 per
modification of diet in renal disease (MDRD) formula (4 variable version) - Acute coronary
or cerebrovascular event within 90 days before randomisation - Heart failure, New York
Heart Association class IV