CPB Versus Sham Treatment for Pain Management in Small Duct Chronic Pancreatitis
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 4/2/2016 |
| Start Date: | October 2013 |
| Contact: | Jayapal Ramesh, MD |
| Email: | jramesh@uab.edu |
| Phone: | 205-934-7964 |
Randomized Single Blinded Control Trial Comparing EUS Guided Celiac Plexus Block (CPB) Versus Sham Treatment for Pain Management in Small Duct Chronic Pancreatitis
This study assesses the pain response to Endoscopic Ultrasound (EUS) guided Celiac Plexus
Block (CPB) treatment in comparison to EUS without a pain block administered. All
participants will receive medications for pain as needed.
Block (CPB) treatment in comparison to EUS without a pain block administered. All
participants will receive medications for pain as needed.
Inclusion Criteria:
- All patients referred to UAB Endoscopy Unit for with known chronic pancreatitis
- Patients referred to the endoscopy unit with abdominal pain with suspicion of chronic
pancreatitis meeting 5 of 9 parenchymal and ductal changes (i.e. lobulations,
hyperechoic stranding, hyperechoic foci, cysts, calcification, irregular duct,
hyperechoic walls, side branch dilations and ductal calculi).
Exclusion Criteria:
- Age <19 years
- Unable to safely undergo EUS for any reason
- Coagulopathy (INR >1.6, Prothrombin Time >18secs, Thrombocytopenia <80,000 cells/ml)
- Unable to consent
- Non-English speaking patients.
- Previously undergone CPB
- Pregnancy and Breast feeding
- Patients with ductal strictures, calcification, pancreatic ductal calculi,
pseudocysts.
- Previous pancreatic surgery
- Previous pseudocyst drainage
- Other documented causes of abdominal pain.
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