Statin Therapy in Acute Influenza
| Status: | Completed |
|---|---|
| Conditions: | Influenza |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/18/2018 |
| Start Date: | October 2013 |
| End Date: | June 30, 2018 |
Influenza (the 'flu') is a common virus infecting approximately 5-20% of the population in
the United States and causing as many as 500,000 deaths worldwide each year. Currently, there
are only a few treatments for influenza infection and none of these target inflammation that
can be caused by the virus. This study will test whether the anti-inflammatory effects of
statins, a class of drugs most often used to treat high cholesterol, will decrease the
severity of illness in patients who are infected with influenza by testing markers of
inflammation in the blood and recording resolution of influenza illness.
the United States and causing as many as 500,000 deaths worldwide each year. Currently, there
are only a few treatments for influenza infection and none of these target inflammation that
can be caused by the virus. This study will test whether the anti-inflammatory effects of
statins, a class of drugs most often used to treat high cholesterol, will decrease the
severity of illness in patients who are infected with influenza by testing markers of
inflammation in the blood and recording resolution of influenza illness.
Inclusion Criteria:(all must be present):
1. Adult patient (age > 18 years)
2. Positive influenza DFA/RAT test result
3. <12 hours from positive influenza test result
Exclusion Criteria:
1. Prior statin medication use (within 30 days of positive influenza test result)
2. Comfort measures only designation or anticipated withdrawal of life-support
3. Atorvastatin specific exclusions:
1. Documented liver cirrhosis or liver dysfunction (AST or ALT greater than 240)
2. Known allergy or intolerance to statins
3. Rhabdomyolysis (CPK elevation > 6x normal)
4. Patients taking the following medications: cyclosporine, HIV protease inhibitors,
hepatitis C protease inhibitor telaprevir, fibric acid derivatives (gemfibrozil),
niacin, azole antifungals (itraconazole, ketoconazole) clarithromycin and
colchicine
4. Patients unable to take oral or nasogastric medications or plan for no oral intake as
part of medical course (eg. emergent surgical intervention)
5. Known pregnancy or active breastfeeding
6. Inability to provide written informed consent for any reason
We found this trial at
1
site
330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Phone: 617-754-2343
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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