Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 4/2/2016 |
| Start Date: | February 2014 |
| Contact: | Joseph Miller, MD |
| Email: | jmiller6@hfhs.org |
| Phone: | 313-916-5419 |
This study investigates if there are hemodynamic alterations in acute stroke that predispose
patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will
target recruitment of acute ischemic stroke patients who present to the ED within 12 hours
of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic
monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral
oximetry.
patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will
target recruitment of acute ischemic stroke patients who present to the ED within 12 hours
of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic
monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral
oximetry.
Inclusion Criteria:
- Suspected ischemic stroke within 12 hours of symptom onset
- NIHSS ≥ 4
- Age 18 to 90 years
Exclusion Criteria:
- Baseline modified Rankin Scale > 3
- Pregnancy
- Intracranial hemorrhage on head CT
- Mechanical ventilation prior to enrollment
- Inadequate temporal windows for TCD analysis
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Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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