Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | December 2007 |
| End Date: | August 2013 |
| Contact: | Francis Kim, MD |
| Email: | fkim@u.washington.edu |
| Phone: | 206 731-8712 |
Study of the Use of Mild Hypothermia in Out-of-hospital Cardiac Arrest Using a Rapid Infusion of 2 Liters of Cold Normal Saline
The overall goal of this study is to determine whether initiating hypothermia in cardiac
arrest patients as soon as possible in the field results in a greater proportion of patients
who survive to hospital discharge compared to standard prehospital/field care.
In this study we will randomize 1,200 cardiac arrest patients who have return of spontaneous
circulation (ROSC) to hypothermia with rapid infusion of 2 liters of 4oC Normal Saline IV
solution over 20 to 30 minutes, IV sedation and muscle paralysis or to standard of care
following ROSC.
The primary objective of this study will be to determine whether induction of mild
hypothermia using an infusion of cold normal saline will improve the proportion of patients
discharged awake from the hospital.
Hypothesis: In cardiac arrest patients who achieve ROSC in the field, initiation of
hypothermia by infusion of cold normal saline will result in a greater proportion of cardiac
arrest patients discharged awake from the hospital compared to standard care.
Inclusion Criteria:
- successful resuscitation from out-of-hospital cardiac arrest by paramedics, defined
by having a palpable pulse
Exclusion Criteria:
- traumatic cause for cardiac arrest
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