Immunosuppressive Effects of Smoking and HIV-1 on the Development of Lung Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Smoking Cessation, HIV / AIDS, Pulmonary |
| Therapuetic Areas: | Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 1/6/2019 |
| Start Date: | March 2014 |
| End Date: | July 2019 |
| Contact: | Thomas B. Campbell, MD |
| Email: | thomas.campbell@ucdenver.edu |
| Phone: | 303-724-4929 |
Immunosuppressive Effects of Smoking and HIV-1 on the Development of Lung Disease.
This study plans to learn more about pulmonary complications of human immunodeficiency
virus/acquired immunodeficiency syndrome (HIV/AIDS). Even though antiretroviral therapy (ART)
has dramatically decreased the number of opportunistic infections and deaths in HIV infected
patients, pulmonary complications (including chronic obstructive pulmonary disease (COPD)
development and pneumonias resulting in decreased lung function) of HIV/AIDS continue to be a
major cause of morbidity and mortality in this population. The mechanisms underlying the
increased risk of COPD and decreased lung function in HIV infected individuals is not well
understand and needs to be studied.
The investigators hypothesize that the immunoregulatory consequences and immunosuppressive
lung milieu secondary to HIV and cigarette smoke combine to increase the risk of lung
infection and injury in HIV infected smokers, hastening the development of COPD. The
mechanisms will be directly tested using blood and bronchial alveolar lavage (BAL) cells from
smokers and nonsmokers with and without HIV infection.
virus/acquired immunodeficiency syndrome (HIV/AIDS). Even though antiretroviral therapy (ART)
has dramatically decreased the number of opportunistic infections and deaths in HIV infected
patients, pulmonary complications (including chronic obstructive pulmonary disease (COPD)
development and pneumonias resulting in decreased lung function) of HIV/AIDS continue to be a
major cause of morbidity and mortality in this population. The mechanisms underlying the
increased risk of COPD and decreased lung function in HIV infected individuals is not well
understand and needs to be studied.
The investigators hypothesize that the immunoregulatory consequences and immunosuppressive
lung milieu secondary to HIV and cigarette smoke combine to increase the risk of lung
infection and injury in HIV infected smokers, hastening the development of COPD. The
mechanisms will be directly tested using blood and bronchial alveolar lavage (BAL) cells from
smokers and nonsmokers with and without HIV infection.
The first component of this study will be a longitudinal, prospective, 24 weeks study of the
effects of HIV-1 infection on innate and acquired immunity in the lung (Cohort A). The second
component of this study will be a cross-sectional, case-control study of lung function and
immune dysregulation of HIV-1 infected persons on long-term ART (Cohort B).
Cohort A will consist of 120 subjects, stratified by HIV-1 and smoking status
Cohort B will consist of 90 subjects stratified by chronic obstructive pulmonary disease
(COPD) and HIV-1 infection.
effects of HIV-1 infection on innate and acquired immunity in the lung (Cohort A). The second
component of this study will be a cross-sectional, case-control study of lung function and
immune dysregulation of HIV-1 infected persons on long-term ART (Cohort B).
Cohort A will consist of 120 subjects, stratified by HIV-1 and smoking status
Cohort B will consist of 90 subjects stratified by chronic obstructive pulmonary disease
(COPD) and HIV-1 infection.
Inclusion Criteria (Cohort A):
- Subjects with chronic HIV-1 infection (Cohorts A1 and A2)
- ART naïve or off all ART for >6 months (Cohorts A1 and A2)
- HIV-1 RNA level >1,000 copies/ml (Cohorts A1 and A2)
- HIV-1 seronegative with no high-risk exposure in the past 30 days (Cohorts A3 and A4)
- 18 years and older (All Cohort A)
- Active cigarette smoker (Cohorts A1 and A3)
Inclusion Criteria (Cohort B):
- Age from 30 to 70 years
- Subjects with chronic HIV-1 infection (Cohorts B1 and B2)
- Subjects on stable 3-drug ART regimen with plasma HIV-1 RNA <50 copies/mL for past 6
months (Cohorts B1 and B2)
- HIV-1 seronegative with no high-risk exposure in the past 30 days (Cohort B3) COPD:
forced expiratory volume at one second (FEV1)/forced vital capacity (FVC) <70% and
forced expiratory volume (FEV), 45-100% of predicted (Cohort B1 and B3)
- Non-COPD: FEV/FVC >70% and an FEV, >80% of predicted (Cohort B2)
Exclusion Criteria (Cohort A and B):
- Pregnancy
- Weight less than 110 pounds (for venipuncture)
- Patient inability to participate in the study and undergo venipuncture and
bronchoscopy procedures
- Use of systemic or inhaled corticosteroids in the past 3 months.
We found this trial at
1
site
13001 E. 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
Principal Investigator: Thomas B. Campbell, MD
Phone: 303-724-4929
University of Colorado Denver The University of Colorado Denver | Anschutz Medical Campus provides a...
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