Therapeutic Imaging Biomarkers for Amyotrophic Lateral Sclerosis

Investigators will study cervical spinal cord chemical concentrations and cervical spinal
cord and brain microstructure in amyotrophic lateral sclerosis(ALS) patients who have had a
stem cell transplant compared to ALS patients who have not had a stem cell transplant.
Investigators intend to determine cervical spinal cord chemical concentrations and cervical
spinal cord and brain microstructure in amyotrophic lateral sclerosis(ALS) patients who have
had a stem cell transplant and compare these to corresponding measures in amyotrophic lateral
sclerosis(ALS) patients who have not had a stem cell transplant.

Inclusion Criteria:

1. 18 years of age or older

2. Subjects with amyotrophic lateral sclerosis -

Exclusion Criteria:

1. Do not have opportunistic central nervous system infection

2. Do not have a history of head injury

3. Do not have cerebrovascular disease

4. Do not have a contraindication for MRI(e.g. cardiac pacemaker, ferromagnetic or
metallic implants).

5. Must not be pregnant -