The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2014 |
| End Date: | December 2016 |
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease
post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood
is drawn from our patients pre-bypass after obtaining the arterial line and administered
back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of
heparin with protamine. In our practice we noticed some variability in the impact of ANH on
postoperative bleeding; with some patients appearing to show more hemostasis after
separation from CPB than others. This is a prospective study to find out if there is an
optimal time period that guarantees the largest amount of functioning platelets and what is
the best practice for drawing and storing of ANH to guarantee the largest amount of
functioning platelets.
post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood
is drawn from our patients pre-bypass after obtaining the arterial line and administered
back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of
heparin with protamine. In our practice we noticed some variability in the impact of ANH on
postoperative bleeding; with some patients appearing to show more hemostasis after
separation from CPB than others. This is a prospective study to find out if there is an
optimal time period that guarantees the largest amount of functioning platelets and what is
the best practice for drawing and storing of ANH to guarantee the largest amount of
functioning platelets.
Inclusion Criteria:
- All patients undergoing cardiac surgery on CPB and are determined to be suitable for
ANH by the cardiac team during the huddle process per our standard protocol.
Exclusion Criteria:
- Patients who are undergoing cardiac surgery on CPB who are determined not to be
suitable candidates for ANH by the cardiac team during the huddle process per our
standard protocol.
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