Phase 1 Safety Study With Intravitreal (IVT) REGN2176-3 in Patients Aged 50 Years and Older With Wet AMD

Inclusion Criteria:

Key Criteria:

Men or women greater than or equal to 50 years of age who provide informed consent and
have active subfoveal choroidal neovascularization (CNV) secondary to wet AMD.

Exclusion Criteria:

1. Any prior treatment with an inhibitor of PDGF (platelet-derived growth factor) or
PDGFR (platelet-derived growth factor receptor)

2. Active neovascular AMD in the fellow eye requiring treatment

3. Scar, fibrosis, or atrophy in the study eye involving the center of the fovea

4. Presence of retinal pigment epithelial tears or rips involving the macula in the
study eye

5. Prior vitrectomy in the study eye

6. Any history of macular hole of stage 2 and above in the study eye

7. Any intraocular or periocular surgery within 3 months of day 1 in the study eye,
except lid surgery

8. History of corneal transplant in the study eye

9. Positive serum human chorionic gonadotropin (hCG)/ urine pregnancy test at the
screening or baseline visit

The information listed above is not intended to contain all considerations relevant to a
patient's potential participation in this clinical trial and not all inclusion/ exclusion
criteria are listed.