Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 4/2/2016 |
| Start Date: | December 2014 |
| End Date: | February 2016 |
The purpose of this study is to understand how simultaneous PET/MR acquisition can provide
novel qualitative and quantitative biomarkers to guide clinical intervention and predict
prognosis of patients with cardiovascular disease.
novel qualitative and quantitative biomarkers to guide clinical intervention and predict
prognosis of patients with cardiovascular disease.
- To compare regional myocardial uptake of FDG on images obtained on a standard PET
camera with the new PET/MR camera, in patients with coronary artery disease.
- To compare viability maps obtained with cardiac MR images and FDG-PET for delineation
of myocardial infarct core and border zone, in patients with coronary artery disease.
- To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with
a previous myocardial infarction.
- To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR
differ from acquisitions obtained independently, with special focus on attenuation
correction methods
- To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and
myocarditis.
- To correlate morphologic characteristics of atherosclerotic disease in the thoracic and
abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of
inflammation.
- To evaluate cardiac strain and myocardial scar burden in obese patients with and
without diabetes.
camera with the new PET/MR camera, in patients with coronary artery disease.
- To compare viability maps obtained with cardiac MR images and FDG-PET for delineation
of myocardial infarct core and border zone, in patients with coronary artery disease.
- To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with
a previous myocardial infarction.
- To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR
differ from acquisitions obtained independently, with special focus on attenuation
correction methods
- To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and
myocarditis.
- To correlate morphologic characteristics of atherosclerotic disease in the thoracic and
abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of
inflammation.
- To evaluate cardiac strain and myocardial scar burden in obese patients with and
without diabetes.
Inclusion Criteria:
- Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for
viability imaging.
Exclusion Criteria:
- Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained
metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and
eGFR less than 45%.
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