Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)



Status:Active, not recruiting
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 55
Updated:4/21/2016
Start Date:December 2013
End Date:December 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Extending Ketamine's Effects in Obsessive-Compulsive Disorder (OCD) With Exposure and Response Prevention (EX/RP)

This study investigates if a single dose of IV Ketamine can rapidly improve
Obsessive-Compulsive Disorder (OCD) symptoms and whether these effect can be maintained with
a condensed course of a type of Cognitive Behavioral Therapy called Exposure and Response
Prevention (EX/RP). You will be compensated for your time and travel. Participants must be
between the ages of 18-55.


Inclusion Criteria:

- Age 18-55

- Physically healthy and not currently pregnant

- Primary Diagnosis of OCD

- Sufficient severity of symptoms

- Currently off all psychotropic medication OR

- Currently on adequate dose of medication for treatment of OCD, but have not achieved
at least partial remission

- Able to provide consent

Exclusion Criteria:

- Psychiatric conditions that make participation unsafe (schizophrenia [either self or
first degree relative e.g. siblings, parents], history of violence, severe
depression, eating disorder, substance dependence [including nicotine])

- Female patients who are either pregnant or nursing

- Planning to commence EX/RP during the period of the study or those who have completed
an adequate dose of EX/RP (defined as 8 or more sessions within 2 months) within 8
weeks prior to enrollment.

period of the study

- Allergy to ketamine

- Participants for whom being off of medication is not clinically recommended

- Medical conditions that make participation unsafe (e.g. high blood pressure, head
injury)

- Currently on medications that make participation unsafe
We found this trial at
1
site
New York State Psychiatric Insitute
New York, New York 10032
?
mi
from
New York, NY
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