Ketamine Patient-Controlled Analgesia for Acute Pain
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Chronic Pain, Hospital, Orthopedic |
| Therapuetic Areas: | Musculoskeletal, Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2014 |
| End Date: | April 2016 |
Ketamine Patient-Controlled Analgesia for Acute Pain in Native Airway Multiple and Orthopedic Trauma Patients: A Randomized, Active Comparator, Blinded Trial
This study will compare ketamine and hydromorphone as alternative patient-controlled
interventions for trauma-related pain. Patients receiving ketamine PCA are expected to
require less total and breakthrough opioid and to have similar or improved objective pain
scores. Patients receiving ketamine are also expected to have shorter duration of
supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary
toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is
further expected to be associated with decreased intensive care unit and hospital lengths of
stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and
lower report of chronic pain syndromes.
interventions for trauma-related pain. Patients receiving ketamine PCA are expected to
require less total and breakthrough opioid and to have similar or improved objective pain
scores. Patients receiving ketamine are also expected to have shorter duration of
supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary
toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is
further expected to be associated with decreased intensive care unit and hospital lengths of
stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and
lower report of chronic pain syndromes.
Inclusion Criteria:
- Age greater than or equal to 18 years
- Total Injury Severity Score greater than 9
- Functioning intravenous catheter present per standard of care
- Patient planned to receive PCA for acute pain per standard of care
- Patient ability to effectively use a PCA device as assessed by the primary attending
trauma service
- Negative pregnancy test for women of childbearing age
Exclusion Criteria:
- Body mass index greater than 35
- History of active psychiatric disease
- Acute or chronic liver or renal failure
- History of heart failure or coronary artery disease
- Patients with documented chronic pain syndrome who use opioids as maintenance
medication in outpatient therapy
- Patients who abuse alcohol and are at high risk for alcohol withdrawal
- Intubated patients
- Glasgow Coma Scale score less than 13, or motor subscore less than 6
- Documented allergy to ketamine, hydromorphone, or lorazepam
- Pregnancy
- Incarceration
We found this trial at
1
site
University of Cincinnati Medical Center Opening in 1823 as the country
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