High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)

Inclusion Criteria:

- History of physician-diagnosed asthma

- History of nasal polyposis

- History of at least two reactions to oral aspirin or other nonselective cyclooxygenase
inhibitor with features of lower airway involvement (cough, chest tightness, wheezing,
dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin

- Age between 18 and 70 years

Exclusion Criteria:

- Current smoking, defined as daily tobacco smoking in the last 6 months and at least
one instance of tobacco smoking in the last 3 months.

- Current pregnancy or breastfeeding

- BMI <20

- History of allergy to fish or any unwillingness to eat fish as a regular part of the
diet

- Use of Zyflo (zileuton) in the last two weeks

- Presence of an implantable cardioverter-defibrillator

- Use of oral steroids in the last two weeks

- Participation in any other clinical trial in the last month

- Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the
cyclooxygenase enzyme during the course of the study