Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Nephrology |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | November 2006 |
| Contact: | Donna S Sanders, DO |
| Email: | dsanders_nch@yahoo.com |
| Phone: | 276-708-7021 |
This will be a randomized controlled trial closely following the original protocol in the
previous study published in JAMA 2004 by Merten et al. Patients will be randomly assigned to
one of two treatment groups. Treatment group A will receive 1cc/kg/hour of 0.9% normal
saline at least 2 hours prior to study beginning and will be continued during and for 6
hours post contrast. Treatment group B will receive 3cc/kg of sodium bicarbonate solution
for one hour prior to procedure then drip rate will be decreased to 1cc/kg/hour during and
for 6 hours post procedure. The sodium bicarbonate solution will be made by adding 3 amps of
bicarbonate to 1L of D5W. Patients in both treatment arms weighing >110kg the initial fluid
bolus and drip will be limited to those patients weighing 110kg. In both treatment arms,
diuretics will be held before and after contrast administration on the day of the study. BMP
will be checked the day of, 24 and 48 hours post contrast administration. The greatest
change in all readings will be used for treatment comparisons. Contrast induced nephropathy
will be defined as a change in serum creatinine of more than 25% from baseline and/or
0.5mg/dL. Urinary pH will also be measured on first spontaneous void following bolus. Vital
signs including blood pressure and oxygen saturation will be documented every 4 hours to
monitor patients closely for signs and symptoms of volume overload
previous study published in JAMA 2004 by Merten et al. Patients will be randomly assigned to
one of two treatment groups. Treatment group A will receive 1cc/kg/hour of 0.9% normal
saline at least 2 hours prior to study beginning and will be continued during and for 6
hours post contrast. Treatment group B will receive 3cc/kg of sodium bicarbonate solution
for one hour prior to procedure then drip rate will be decreased to 1cc/kg/hour during and
for 6 hours post procedure. The sodium bicarbonate solution will be made by adding 3 amps of
bicarbonate to 1L of D5W. Patients in both treatment arms weighing >110kg the initial fluid
bolus and drip will be limited to those patients weighing 110kg. In both treatment arms,
diuretics will be held before and after contrast administration on the day of the study. BMP
will be checked the day of, 24 and 48 hours post contrast administration. The greatest
change in all readings will be used for treatment comparisons. Contrast induced nephropathy
will be defined as a change in serum creatinine of more than 25% from baseline and/or
0.5mg/dL. Urinary pH will also be measured on first spontaneous void following bolus. Vital
signs including blood pressure and oxygen saturation will be documented every 4 hours to
monitor patients closely for signs and symptoms of volume overload
Inclusion Criteria:
- Stage III Chronic Kidney Disease (GFR 30-60ml/min per 1.73m2 calculated by using MDRD
equation)
- Inpatients at Norton Community Hospital scheduled to undergo diagnostic CT Scan using
contrast between the hours of 7am and 6pm
- 18+ years of age
Exclusion Criteria
- Current clinical diagnosis of exacerbated congestive heart failure
- Creatinine >8 mg/dL
- Change in serum Cre of at least 0.5mg/dL during previous 24hours
- Pre-existing dialysis patient
- Multiple myeloma
- Uncontrolled hypertension (definition: treated SBP >160mmHg or DBP >100mmHg
- Exposure to contrast 48 hours prior to study
- Allergy to contrast dye
- Pregnancy
- Patient has received pressor agents, fendolapam, mannitol, or mucomyst at time of study
- Acute myocardial infarction
Subjects: Consecutive samples of all CPSC inpatients who meet the above inclusion criteria
Allocation Assignment: Patients who meet inclusion criteria and agree to participate in the
study will pick a concealed number out of an open envelope. That number (between 1- 656)
will correlate with a number on a sealed opaque envelope. Inside the opaque envelope will be
a chart sticker. The chart sticker will have the words either normal saline or sodium
bicarbonate. The envelope will not be opened until all patient information (ie. Patient ID
sticker) is placed on the original chosen envelope. Then the chart sticker will be removed
and placed on the chart
Protocol Outline:
This will be a randomized controlled trial closely following the original protocol in the
previous study. Patients will be randomly assigned to one of two treatment groups. Treatment
group A will receive 1cc/kg/hour of 0.9% normal saline at least 2 hours prior to study
beginning and will be continued during and for 6 hours post contrast. Treatment group B will
receive 3cc/kg of sodium bicarbonate solution for one hour prior to procedure then drip rate
will be decreased to 1cc/kg/hour during and for 6 hours post procedure. The sodium
bicarbonate solution will be made by adding 3 amps of bicarbonate to 1L of D5W. Patients in
both treatment arms weighing >110kg the initial fluid bolus and drip will be limited to
those patients weighing 110kg. In both treatment arms, diuretics will be held before and
after contrast administration on the day of the study. BMP will be checked the day of, 24
and 48 hours post contrast administration. The greatest change in all readings will be used
for treatment comparisons. Contrast induced nephropathy will be defined as a change in serum
creatinine of more than 25% from baseline and/or 0.5mg/dL. Urinary pH will also be measured
on first spontaneous void following bolus. Vital signs including blood pressure and oxygen
saturation will be documented every 4 hours to monitor patients closely for signs and
symptoms of volume overload
- Stage III Chronic Kidney Disease (GFR 30-60ml/min per 1.73m2 calculated by using MDRD
equation)
- Inpatients at Norton Community Hospital scheduled to undergo diagnostic CT Scan using
contrast between the hours of 7am and 6pm
- 18+ years of age
Exclusion Criteria
- Current clinical diagnosis of exacerbated congestive heart failure
- Creatinine >8 mg/dL
- Change in serum Cre of at least 0.5mg/dL during previous 24hours
- Pre-existing dialysis patient
- Multiple myeloma
- Uncontrolled hypertension (definition: treated SBP >160mmHg or DBP >100mmHg
- Exposure to contrast 48 hours prior to study
- Allergy to contrast dye
- Pregnancy
- Patient has received pressor agents, fendolapam, mannitol, or mucomyst at time of study
- Acute myocardial infarction
Subjects: Consecutive samples of all CPSC inpatients who meet the above inclusion criteria
Allocation Assignment: Patients who meet inclusion criteria and agree to participate in the
study will pick a concealed number out of an open envelope. That number (between 1- 656)
will correlate with a number on a sealed opaque envelope. Inside the opaque envelope will be
a chart sticker. The chart sticker will have the words either normal saline or sodium
bicarbonate. The envelope will not be opened until all patient information (ie. Patient ID
sticker) is placed on the original chosen envelope. Then the chart sticker will be removed
and placed on the chart
Protocol Outline:
This will be a randomized controlled trial closely following the original protocol in the
previous study. Patients will be randomly assigned to one of two treatment groups. Treatment
group A will receive 1cc/kg/hour of 0.9% normal saline at least 2 hours prior to study
beginning and will be continued during and for 6 hours post contrast. Treatment group B will
receive 3cc/kg of sodium bicarbonate solution for one hour prior to procedure then drip rate
will be decreased to 1cc/kg/hour during and for 6 hours post procedure. The sodium
bicarbonate solution will be made by adding 3 amps of bicarbonate to 1L of D5W. Patients in
both treatment arms weighing >110kg the initial fluid bolus and drip will be limited to
those patients weighing 110kg. In both treatment arms, diuretics will be held before and
after contrast administration on the day of the study. BMP will be checked the day of, 24
and 48 hours post contrast administration. The greatest change in all readings will be used
for treatment comparisons. Contrast induced nephropathy will be defined as a change in serum
creatinine of more than 25% from baseline and/or 0.5mg/dL. Urinary pH will also be measured
on first spontaneous void following bolus. Vital signs including blood pressure and oxygen
saturation will be documented every 4 hours to monitor patients closely for signs and
symptoms of volume overload
Inclusion Criteria:
- Stage III Chronic Kidney Disease (GFR 30-60ml/min per 1.73m2 calculated by using MDRD
equation)
- Inpatients at Norton Community Hospital scheduled to undergo diagnostic CT Scan using
contrast between the hours of 7am and 6pm
- 18+ years of age
Exclusion Criteria:
- Exclusion Criteria
- Current clinical diagnosis of exacerbated congestive heart failure
- Creatinine >8 mg/dL
- Change in serum Cre of at least 0.5mg/dL during previous 24hours
- Pre-existing dialysis patient
- Multiple myeloma
- Uncontrolled hypertension (definition: treated SBP >160mmHg or DBP >100mmHg
- Exposure to contrast 48 hours prior to study
- Allergy to contrast dye
- Pregnancy
- Patient has received pressor agents, fendolapam, mannitol, or mucomyst at time of
study
- Acute myocardial infarction
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