Bone Marrow Aspirate Concentration in Posterior Cervical Fusion
| Status: | Terminated |
|---|---|
| Conditions: | Neurology, Neurology, Orthopedic, Hematology |
| Therapuetic Areas: | Hematology, Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 11/1/2018 |
| Start Date: | February 2014 |
| End Date: | April 5, 2017 |
The purpose of this research is to test if that combining bone marrow aspirate (removing bone
marrow with a needle) concentration with locally harvested (collected) autograft (patient's
own bone from another part of the body) for use as the bone graft results in equal rates of a
successful procedure (fusion), as compared to current best practice in high-risk patients
undergoing posterior cervical fusion.
Hypothesis: Bone marrow aspirate concentration combined with locally harvested autograft
results in equivalent rates of bony fusion, as compared to current best practice in high-risk
patients undergoing posterior cervical decompression and fusion.
marrow with a needle) concentration with locally harvested (collected) autograft (patient's
own bone from another part of the body) for use as the bone graft results in equal rates of a
successful procedure (fusion), as compared to current best practice in high-risk patients
undergoing posterior cervical fusion.
Hypothesis: Bone marrow aspirate concentration combined with locally harvested autograft
results in equivalent rates of bony fusion, as compared to current best practice in high-risk
patients undergoing posterior cervical decompression and fusion.
Inclusion Criteria:
- Age between 18 and 75
- Have at least one of the following high risk qualifications: BMI >30, Rheumatoid
Arthritis, Osteoporosis, Current smoker
- Able to cooperate in the completion of standardized outcome measures (multiple
questionnaires)
- Willing and able to comply with study protocol
- Symptomatic cervical myelopathy and/or radiculopathy
- Scheduled for cervical alignment, allowing management with a posterior approach
Exclusion Criteria:
- MRI incompatible device
- History of prior cervical instrumentation
- Requires an instrumented anterior cervical fusion
- History of underlying neurological condition affecting the cervical spine (MS,
Amyotrophic Lateral Sclerosis, HIV)
- Pre-existent neurologic disorder or mental disorder that would preclude accurate
evaluation (psychiatric disease, Parkinson's disease, Alzheimer's disease)
- History of previous cervical fusion at the operative site
- Pregnant
- Active malignancy
- Previous history of posterior cervical decompression
We found this trial at
2
sites
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660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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