Enhancing Function in Later Life: Exercise and Functional Network Connectivity
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 25 - Any |
| Updated: | 4/17/2018 |
| Start Date: | April 2014 |
| End Date: | January 2019 |
| Contact: | Angela D Bryan, Phd |
| Email: | angela.bryan@colorado.edu |
| Phone: | 303-492-8264 |
Physiological and neurocognitive changes experienced as a result of increasing age may
influence socioemotional functioning and economic behaviors, yet, the mechanisms through
which these changes occur are not well understood. Studies have also shown that aerobic
exercise may protect against age-related cognitive decline in other domains. This research is
designed to test the hypothesis that aerobic exercise will enhance social, emotional and
economic functioning in older adults, and that these effects will occur via the effect of
exercise on neurocognitive structure and function assessed via magnetic resonance imaging
(MRI). Advancing our knowledge of the mechanisms that influence emotional, social and
economic functioning could inform the development of targeted treatments and prevention
programs for older adults.
influence socioemotional functioning and economic behaviors, yet, the mechanisms through
which these changes occur are not well understood. Studies have also shown that aerobic
exercise may protect against age-related cognitive decline in other domains. This research is
designed to test the hypothesis that aerobic exercise will enhance social, emotional and
economic functioning in older adults, and that these effects will occur via the effect of
exercise on neurocognitive structure and function assessed via magnetic resonance imaging
(MRI). Advancing our knowledge of the mechanisms that influence emotional, social and
economic functioning could inform the development of targeted treatments and prevention
programs for older adults.
Inclusion Criteria:
- Age 25-35 for younger adults, and age 60 or over for older adults
- Sedentary (i.e., < 60 minutes per week of moderate physical activity in the past
6-months)
- Able to make fewer than 3 errors on the Pfeiffer Mental Status192
- Willing to accept random assignment to condition (older adults)
- Physically capable of safely engaging in moderate exercise activity (i.e., no
injuries, physical impairments, or pre-existing contraindications) as assessed by a
study physician
- Able to successfully complete a maximal exercise test without evidence of cardiac or
other abnormalities
- Planning to remain in the Boulder-Denver metro area for the next 4 months (older
adults)
Exclusion Criteria:
- Are a heavy smoker (>20 pack years)
- Are diabetic
- Have a body size exceeding the capacity of the magnetic resonance imaging machine
(approximately 23" in diameter)
- Are on antipsychotic medications
- Are currently under treatment for any psychiatric disorder, including clinical
depression, Alzheimer's, or dementia
- Are currently pregnant
- Have magnetic resonance imaging contraindications (i.e., non-removable metallic
implants, claustrophobia, traumatic brain injury, current pregnancy, etc.)
We found this trial at
1
site
University of Colorado, Boulder As the flagship university of the state of Colorado, CU-Boulder is...
Click here to add this to my saved trials
