Augmented Multimodal Neurologic Monitoring in High Risk Survivors of Cardiac Arrest

Cardiac arrest is the most common cause of death in the United States and as many as 590,000
Americans suffering a cardiac arrest each year. Despite advances in care, as many as 50 to
89% of patients who are resuscitated after a cardiac arrest die in the hospital. Brain injury
is the most common cause of death and disability after cardiac arrest. The investigators use
advanced brain monitoring in patients who are at high risk of death after cardiac arrest,
with the goal of preventing ongoing brain injury. The most common problem the investigators
have observed is low oxygen levels in the brain, which is often very difficult to treat.

In this study, the investigators plan to use two additional brain monitors in the care of
these high risk patients: a monitor for seizures and a monitor of the amount of blood flow in
the brain. The investigators will use these to detect and treat potential causes of low brain
oxygen levels. The main hypotheses are that electrical events in the brain such as seizures
and "spreading depolarizations" will occur during times of low brain tissue oxygen level, and
that treating these events and low blood flow will reduce the rate of low brain oxygen
levels.