Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease

Inclusion Criteria:

- Between the ages of 18 and 75 years

- Symptomatic, single-level degenerative lumbar disc disease, spondylosis or
spondylolisthesis

- Failed conservative treatments

- Low risk for non-union

- Must be candidates for single-level, posteriolateral lumbar spine fusion

- Must be able and willing to give Informed Consent

- English-speaking

Exclusion Criteria:

- Smoker (any smoking ≤3 months prior to consent); (Patel et al. 2013)

- Patients with poorly controlled diabetes mellitus (HgbA1c > 7%)

- Documented osteoporosis

- Prior lumbar spinal surgery at the same spinal level, or immediately adjacent spine
level, to the level being operated on

- Back pain due to infection, tumour, or metabolic bone disease

- Terminal disease, such as HIV infection, neoplasm

- Autoimmune disease, such as rheumatoid arthritis

- Morbid obesity (body mass index (BMI) of 35 kg/m2)

- Major psychiatric illness in the last year

- History of alcohol or drug abuse in the last year

- Pregnant women