DFD01 Spray vs Comp01 Lotion HPA Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis

Inclusion Criteria:

1. Subjects must present with a clinical diagnosis of stable (at least 3 months) plaque
psoriasis.

2. Subjects with psoriasis involving 20 to 50% BSA, not including the face, scalp,
groin, axillae and other intertriginous areas.

3. Subjects must have an IGA grade of at least 3 (moderate) at the Baseline Visit

4. Subjects whose results from the screening ACTH stimulation test are considered normal
(cortisol level >18 ug/dL at 30 minutes post stimulation) and show no other signs of
abnormal HPA function or adrenal response. -

Exclusion Criteria:

1. Current diagnosis of unstable forms of psoriasis including guttate, erythrodermic,
exfoliative or pustular psoriasis.

2. History of organ transplant requiring immunosuppression, HIV, or other
immunocompromised state.

3. Have received treatment for any type of cancer within 5 years of the Baseline Visit
except skin cancer and cervical cancer (in situ) are allowed if at least 1 year
before the Baseline Visit.

4. Use within 60 days prior to the Baseline Visit of: 1) immunosuppressive drugs (e.g.,
tacrolimus, pimecrolimus), or 2) systemic antipsoriatic treatment (e.g.,
methotrexate, cyclosporine, hydroxyurea)

5. Use within 30 days prior to the Baseline Visit of: 1) topical antipsoriatic drugs
(salicylic acid, anthralin, coal tar, calcipotriene)2) PUVA therapy, 3) systemic
anti-inflammatory agents (e.g., mycophenolate mofetil, sulfasalazine, 6-thioguanine),
or 4) UVB therapy.

6. Use within 30 days prior to the Screening Visit of any product containing
corticosteroids. Inhaled, intraocular, intranasal, etc. steroids are not allowed.

7. Subjects who have an abnormal sleep schedule or work at night.

8. Subjects with a known history of acute adrenal crisis, Addison's disease or decreased
adrenal output, low pituitary function or pituitary tumors.

9. Subjects who have a history of an adverse reaction to cosyntropin injection or
similar test reagents.