Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
| Status: | Completed |
|---|---|
| Conditions: | Parkinsons Disease, Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 1/24/2018 |
| Start Date: | March 2014 |
| End Date: | November 29, 2017 |
Local Field Potentials Recorded From Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson's Disease, Essential Tremor or Dystonia
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the
motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia. Over 100,000
patients worldwide have now been implanted with DBS devices. The DBS target regions in the
brain are the Subthalamic nucleus (STN), the Internal Segment of Globus Pallidus (GPi), or
the Ventral Intermediate Nucleus of the Thalamus (VIM). In order to place the DBS electrode
in the target location, a combination of two 3D imaging techniques; 3D MRI and CT, are used.
Data are also collected from individual nerve cells to help find the best location for the
DBS electrode in each patient. This electrode recording takes place during the standard
surgical implantation of the DBS electrode, and is part of the standard clinical technique.
The investigators plan to collect additional data from populations of neurons during the DBS
surgery in an effort to further improve the placement of the DBS electrode. These "Local
Field Potentials", LFPs, represent the activity of the collection of neurons surrounding the
tip of the electrode, and will be measured during surgery along the path used for the
placement of the DBS electrode. The goal of this project is to determine whether this
additional data from surrounding neurons will help with optimal placement of the DBS
electrode.
motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia. Over 100,000
patients worldwide have now been implanted with DBS devices. The DBS target regions in the
brain are the Subthalamic nucleus (STN), the Internal Segment of Globus Pallidus (GPi), or
the Ventral Intermediate Nucleus of the Thalamus (VIM). In order to place the DBS electrode
in the target location, a combination of two 3D imaging techniques; 3D MRI and CT, are used.
Data are also collected from individual nerve cells to help find the best location for the
DBS electrode in each patient. This electrode recording takes place during the standard
surgical implantation of the DBS electrode, and is part of the standard clinical technique.
The investigators plan to collect additional data from populations of neurons during the DBS
surgery in an effort to further improve the placement of the DBS electrode. These "Local
Field Potentials", LFPs, represent the activity of the collection of neurons surrounding the
tip of the electrode, and will be measured during surgery along the path used for the
placement of the DBS electrode. The goal of this project is to determine whether this
additional data from surrounding neurons will help with optimal placement of the DBS
electrode.
Inclusion Criteria:
- Subjects included in this study will be those who are planning to undergo DBS surgery
because of their underlying idiopathic Parkinson's disease, Essential Tremor, or
Dystonia--all FDA-approved indications for the implantation of DBS devices.
Exclusion Criteria:
- Subjects with the most advanced symptoms of PD (stage V in the Hoehn and Yahr rating
scale).
- Subjects who are not planning to undergo DBS surgery.
- Subjects not candidates for DBS surgery based on clinical criteria.
We found this trial at
1
site
12605 East 16th Avenue
Aurora, Colorado 80045
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Aviva Abosch, MD, Ph.D.
Phone: 303-724-4134
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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