Association of Periostin Levels and Chronic Sinusitis
| Status: | Recruiting |
|---|---|
| Conditions: | Sinusitis |
| Therapuetic Areas: | Otolaryngology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | September 2014 |
| Contact: | John Steinke |
| Email: | js3ch@virginia.edu |
| Phone: | 434-982-3270 |
The purpose of this study is to see if a protein in blood, called periostin, can determine
if patients have chronic sinusitis. This protein is in everyone's body, but the level of the
protein may indicate certain conditions such as chronic sinusitis. The investigators are
interested in testing levels of periostin to see if they are higher or lower than patients
without chronic sinusitis, just as periostin is higher in patients with asthma. All patients
enrolled in this study will have chronic sinusitis without asthma.
if patients have chronic sinusitis. This protein is in everyone's body, but the level of the
protein may indicate certain conditions such as chronic sinusitis. The investigators are
interested in testing levels of periostin to see if they are higher or lower than patients
without chronic sinusitis, just as periostin is higher in patients with asthma. All patients
enrolled in this study will have chronic sinusitis without asthma.
Inclusion Criteria:
- Patients with sinus disease which requires surgical intervention
- Ability to understand and give informed consent
Exclusion Criteria:
- Previous diagnosis of asthma
- Positive methacholine challenge at screening
- Diagnosis of cystic fibrosis
- Concomitant use of systemic corticosteroids (except for those prescribed as part of
standard pre-surgical treatment)
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