Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease

Inclusion Criteria:

1. Voluntarily provide informed consent, or have a legally authorized representative
(LAR) provide informed consent with subject assent, in accordance with local
regulations and governing Institution Review Board (IRB) requirements prior to any
procedures or evaluations performed specifically for the sole purpose of the study
(other than the Montreal Cognitive Assessment (MoCA) to assess capacity to provide
informed consent). Capacity to provide informed consent will be determined by the MoCA
and investigator judgment according to the following:

- Subjects with scores of greater than or equal to 21 on the MoCA and, in the
judgment of the investigator, have the capacity to provide valid informed
consent, can give consent.

- Subjects with scores of less than 21 but greater than or equal to 18 on the MoCA
and, in the judgment of a mental health professional (independent of the
investigator) have the capacity to provide valid informed consent, may give
consent.

- Subjects with scores less 21 but greater than or equal to 18 on the MoCA, who
lack the capacity to give valid informed consent, in the judgment of a mental
health professional (independent of the investigator), will need an LAR to
provide informed consent with assent by the subject.

- Subjects with scores of less than 18 on the MoCA will have an LAR provide
informed consent with assent by the subject.

2. Have a clinical diagnosis of HD, confirmed by either CAG repeat number of greater than
or equal to 39 or a positive family history (a first degree relative with a clinical
diagnosis of HD) if CAG repeat number is not known.

3. Are age greater than or equal to 18 and less than or equal to 65 years at the
screening visit (Visit 1).

4. Have a UHDRS Total Functional Capacity greater than or equal to 7 at Visit 1.

5. If currently taking antipsychotic medication(s), have been on a stable regimen for at
least 60 days prior to randomization.

6. Are fluent in English.

7. If female, are either a) not of childbearing potential (i.e., surgically sterilized or
post-menopausal for more than 1 year) or b) have a negative pregnancy test and if
sexually active must agree to use a medically reliable form of contraception
throughout the study. Acceptable methods of contraception include a reliable
intrauterine device, hormonal contraception or spermicide in combination with a
barrier method.

8. If male, are either a) not of reproductive potential or b) if sexually active must
agree to use a medically reliable form of contraception throughout the study.
Acceptable methods of birth control include spermicide in combination with a barrier
method, or subjects' female partner is willing to use medically acceptable methods of
birth control.

9. Have normal clinical laboratory test results and ECG, or results with minor
deviations, which are not considered to be clinically significant by the investigator.

Exclusion Criteria:

1. Have a history or presence of significant cardiovascular, respiratory, hepatic, renal,
gastrointestinal, endocrine, or neurological disorders other than HD which, in the
opinion of the investigator, increases the risk of the study drug or may confound the
interpretation of study measures.

2. Have unstable or severe depression, in the opinion of the investigator.

3. Have alcohol or drug abuse or dependence, as defined by the Diagnostic and Statistical
Manual of Mental Disorders, 4th Edition, Text Revision.

4. Have received treatment with an investigational drug or device within 60 days prior to
Visit 1.

5. Are pregnant or lactating.

6. Have serum alanine transaminase or aspartate transaminase greater than two times upper
limit of normal at screening.

7. Have hemoglobin, white blood cell count, absolute neutrophil count, or platelet count
outside the normal range at screening.

8. Are an employee of Omeros, an investigator, or study staff member, or their immediate
family member.