Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease

This will be an open-label, non-randomized multi-center patient sponsored study of Autologous
SVF (AD-SVF) implantation after liposuction using an IV delivery system and Inhalation
infusion. AD-SVF will be derived from the patient's adipose-derived tissue. Liposuction using
local anesthesia and syringe collection will be performed to collect the adipose tissue
specimen for subsequent processing to isolate the stem cells. The cells will be delivered
intravenously.

The adipose tissue specimen will be collected from the patient's abdomen or applicable area
using tumescent syringe liposuction. The adipose tissue is transferred to the laboratory for
separation of the adipose tissue-derived stem cells, which are then transferred for IV
delivery. The number of cells injected will vary depending on the amount of tissue processed
and the number of cells obtained from the process.

Inclusion Criteria:

- A prior diagnosis of moderate or severe COPD

- GOLD III and IV

- Age between 25 and 80 years

- Up to date on all age and gender appropriate cancer screening per American Cancer
Society

Exclusion Criteria:

- Females who are pregnant or nursing or females of childbearing potential who are
unwilling to maintain contraceptive therapy for the duration of the study

- Life expectancy < 6 months due to concomitant illnesses.

- Exposure to any investigational drug or procedure within 1 month prior to study entry
or enrolled in a concurrent study that may confound results of this study.

- Active infectious disease patients known to have tested positive for HIV, HTLV, HBV,
HCV, CMV (IgM > IgG) and/or syphilis. will have an expert consulted as to patient
eligibility based on the patient's infectious status

- Any illness which, in the Investigator's judgment, will interfere with the patient's
ability to comply with the protocol, compromise patient safety, or interfere with the
interpretation of the study results

- Patients on chronic immunosuppressive transplant therapy

- Known drug or alcohol dependence or any other factors which will interfere with the
study conduct or interpretation of the results or who in the opinion of the
investigator are not suitable to participate.

- Severe asthma that would contraindicate surgery

- History of cancer (other than non-melanoma skin cancer or in-situ cervical cancer) in
the last five years.

- Unwilling and/or not able to give written informed consent.