Retapamulin Microdialysis Feasibility Study

Inclusion Criteria:

Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests. A subject
with a clinical abnormality or laboratory parameters outside the reference range for the
population being studied may be included only if the Investigator and the GlaxoSmithKline
(GSK) Medical Monitor agree that the finding is unlikely to introduce additional risk
factors and will not interfere with the study procedures. Subjects with clinically
significant lab values outside the normal range should always be excluded from enrollment.

- The subject is able to understand and comply with protocol requirements, instructions
and protocol-stated restrictions and is likely to complete the study as planned.
Subject is willing to provide informed consent.

- Does not use medications containing Retapamulin while participating in the study.

- Male or female between 18 and 55 years of age inclusive, at the time of signing the
informed consent.

- Body Mass Index within the range 18.5 to 32 kilogram/ meter^2 (inclusive).

- The following normal ranges for blood pressure and heart rate are given as a guide:
Systolic blood pressure 90 to 140 milimeter of Mercury (mmHg), Diastolic blood
pressure 60 to 90 mmHg, and Heart rate 45 to 100 beats per minute (bpm). The
investigator may interpret screening vital sign data based on the subject's age,
physical state and level of fitness. Subjects with vital sign readings marginally
outside the normal range may be included in the study if in the investigator's
opinion these values are not clinically significant and will not present a safety
risk or affect study assessments.

- A female subject is eligible to participate if she is of non-childbearing potential
(defined as pre-menopausal females with a documented tubal ligation or hysterectomy;
or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable
cases a blood sample with simultaneous follicle stimulating hormone > 40 milli
international unit/mililiter (mL) and estradiol < 40 picogram/ml [<147
picomoles/Liter] is confirmatory]. Females on hormone replacement therapy and whose
menopausal status is in doubt will be required to use one of the contraception
methods) or Child-bearing potential and agrees to use one of the contraception
methods for an appropriate period of time (as determined by the product label or
investigator) prior to the start of dosing to sufficiently minimize the risk of
pregnancy at that point. Female subjects must agree to use contraception until study
completion (i.e. follow-up phone call). Male subjects with female partners of
child-bearing potential must agree to use one of the contraception methods. This
criterion must be followed from the time of the first dose of study medication until
study completion (i.e. follow-up phone call).

- Alanine aminotransferase, alkaline phosphatase and bilirubin <= 1.5x Upper limit of
normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated
and direct bilirubin <35 percent).

- QT interval corrected for Heart rate (QTc), QTcB (Bazett's formula) or QTcF
(Fridericia's formula) < 450 millisecond (msec); or QTc < 480 msec in subjects with
Bundle Branch Block.

- Does not currently smoke cigarettes or tobacco and has not smoked within the past 12
months prior to the study.

- Does not consume alcohol 72 hours prior to the start of and during the study

Exclusion Criteria:

- Unwillingness or inability to follow the procedures outlined in the protocol

- Subject is mentally or legally incapacitated.

- History of current significant medical illness including cardiovascular thrombotic
events, myocardial infarction, stroke or other cardiac disease, hypertension, peptic
ulcer disease or gastrointestinal bleeding, skin disorders, hematological disease,
bronchospastic respiratory disease, asthma, diabetes mellitus, renal or hepatic
insufficiency, or any other illness that the investigator deems clinically
significant for exclusion of the subject from the study.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- History of skin conditions including atopic dermatitis, dry skin, or ichtyosis
vulgaris.

- Surgical history within 3 months prior to the start of the study.

- Clinically significant acute illness 7 days prior to study start.

- Excessive hair, tattooing, scar tissue, or other tissue damage at the application
site that could affect drug recovery or patient safety.

- Use of topical moisturizers (does not include facial moisturizers) 48 hours before
the start of and during the study.

- Strenuous exercise 48 hours before the start of and during the study.

- Unable to refrain from the use of non-prescription drugs, including non- steroidal
ant-inflammatory drugs (NSAIDS), vitamins, herbal and dietary supplements (including
St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer)
or 5 half-lives (whichever is longer) prior to the first dose of study medication,
unless in the opinion of the Investigator and GSK Medical Monitor the medication will
not interfere with the study procedures or compromise subject safety.

- History of regular alcohol consumption within 6 months of the study defined as an
average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 gram of alcohol: 12 ounces (360mL) of beer; 5 ounces (150mL) of
wine; or 1.5 ounce (45mL) of 80 proof distilled spirits.

- A positive pre-study drug/alcohol screen.

- Pregnant females as determined by positive serum human chorionic gonadotropin (hCG)
at screening or urine hCG test prior to dosing.

- Lactating females.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Employees of the investigator or study center, with direct involvement in the
proposed study or similar studies including family members of the employees or the
investigator