Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy

People infected with HIV who are taking cART and have low viral load levels may still have
reservoirs of HIV remaining in their body. BMS-936559 is a drug that has been studied in
previous clinical trials to treat various types of cancer. The purpose of this study is to
evaluate the safety, PK, and immunotherapeutic activity of a single dose of BMS-936559
(administered by an IV infusion) in HIV-infected people who are receiving cART and who have
viral loads below the limit of detection. Researchers will also evaluate whether BMS-936559
can reduce hidden reservoirs of HIV.

Participants will be enrolled in four cohorts. Within each cohort, participants will be
randomly assigned to receive BMS-936559 (Cohort 1: 0.3 mg/kg; Cohort 2: 1 mg/kg; Cohort 3: 3
mg/kg; or Cohort 4: 10 mg/kg) or placebo. The four cohorts will be enrolled sequentially,
with researchers reviewing safety data of the cohort before enrolling participants in the
next cohort.

Prior to study entry, all participants must have an eye exam and an electrocardiogram (ECG).
At study entry, participants will undergo a medical and medication history review, physical
examination, an eye exam, and a blood collection. Some female participants will have a
pregnancy test. All participants will then receive a single IV infusion of their assigned
dose of BMS-936559 or placebo. The infusion will occur over a period of 60 minutes, and
participants will remain in the clinic for observation for an additional 12 hours.
Additional study visits will occur at Days 3, 7, 14, 28, and Weeks 10, 16, 24, 36, and 48.
These study visits may include a physical examination, blood collection, adherence
assessments, and PK evaluations. Some participants may have additional eye exams during the
study, on an as-needed basis.

Inclusion Criteria:

- HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or
chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and
confirmed by a licensed Western blot or a second antibody test by a method other than
the initial rapid HIV and/or E/CIA, or by HIV-1 antigen, plasma HIV-1 RNA assay. More
information on this criterion is available in the protocol.

- Receiving a stable cART regimen containing at least three agents (not including
ritonavir if less than a 200 mg total daily dose) with no changes in the components
of their antiretroviral therapy for at least 90 days prior to study entry. NOTE: One
of the agents must include an integrase inhibitor, a non-nucleoside reverse
transcriptase inhibitor (NNRTI), or a boosted protease inhibitor (PI).

- CD4 cell count greater than or equal to 350 cells/mm^3 obtained within 90 days prior
to study entry at any U.S. laboratory that has a clinical laboratory improvement
amendments (CLIA) certification or its equivalent

- Plasma HIV-1 RNA below detected limit obtained by Food and Drug Administration
(FDA)-approved assays (limit of detection: 75, 50, 40, or 20) for greater than or
equal to 2 years on cART. Participants must have at least one documented HIV-1 RNA
less than the limit of detection 12-24 months prior to screening and one HIV-1 RNA
less than the limit of detection within 12 months prior to screening. NOTE: A single
unconfirmed plasma HIV-1 RNA greater than the limit of detection but less than 1,000
copies/mL is allowed if followed by HIV-1 RNA below detectable limits, but none in
the 6 months prior to screening.

- Plasma HIV-1 RNA level of less than 40 copies/mL obtained by the Abbott m2000 assay
or less than 20 copies/mL by the Roche Taqman v2.0 assay within 90 days prior to
entry. The protocol team should be notified as soon as possible if the HIV-1 RNA
level is above the limit of detection for either assay.

- Plasma HIV-1 RNA greater than or equal to 0.4 copies/mL by single copy assay (SCA)
within 120 days prior to entry

- The following laboratory values obtained within 60 days prior to entry by any U.S.
laboratory that has a CLIA certification or its equivalent:

- Absolute neutrophil count (ANC) greater than or equal to 1,000 cells/mm^3

- Hemoglobin greater than or equal to 14.0 g/dL for men and greater than or equal
to 12.0 g/dL for women

- Platelet count greater than or equal to 75,000/mm^3

- Creatinine clearance greater than or equal to 50 mL/min estimated by the
Cockcroft-Gault equation. NOTE: A program for calculating creatinine clearance
by the Cockcroft-Gault method is available on www.fstrf.org.

- Alanine aminotransferase (ALT) (SGPT) less than or equal to 2.5 times upper
limit of normal (ULN)

- A.M. cortisol within normal limits

- Fasting blood sugar within normal limits

- Total bilirubin less than or equal to 1.6 x ULN. NOTE: If the participant is on
an atazanavir-containing therapy then a direct bilirubin should be measured
instead of the total bilirubin and must be less than or equal to 1.0 mg/dL.

- The following laboratory values obtained within 90 days prior to entry by any U.S.
laboratory that has a CLIA certification or its equivalent:

- Thyroid stimulating hormone (TSH) and free T4 level within normal limits

- Hemoglobin A1c (HgbA1c) within normal limits

- Hepatitis C virus (HCV) antibody negative result within 90 days prior to study entry
or, if the HCV antibody result is positive, a negative HCV RNA result prior to study
entry. Participants who have received HCV treatment in the last 5 years will be
excluded.

- Negative hepatitis B surface antigen (HBsAg) result obtained within 90 days prior to
study entry

- Karnofsky performance score greater than or equal to 90 within 60 days prior to entry

- Documentation of the availability of the stored pre-entry plasma specimens for HIV-1
RNA SCA determination and stored pre-entry peripheral blood mononuclear cell (PBMC)
specimens for CD8 T-cell assays. Sites must receive confirmation from the processing
lab via phone, e-mail, or fax, that specimens have been entered into the AIDS
Clinical Trials Group's (ACTG's) Laboratory Data Management System (LDMS).

- Ability and willingness of participant or legal guardian/representative to provide
informed consent

- Ability and willingness of participant to continue cART throughout the study

- Ability to construct a fully active alternative cART regimen in the event of
virologic failure on the current ART regimen

- An ophthalmology exam within 180 days prior to entry and a copy of the results of the
exam. NOTE: Ophthalmologic exams done to meet enrollment criteria must be performed
by a licensed ophthalmologist within 180 days of the study entry visit. Results of
the exam must be available for review and made part of the clinical record.

Exclusion Criteria:

- History of malignancy within the last 5 years or current malignancy requiring
cytotoxic therapy. NOTE: A history of non-melanoma skin cancer (e.g., basal cell
carcinoma or squamous cell skin cancer) is not exclusionary.

- History of HIV-related opportunistic infections within the last 5 years. More
information on this criterion is available in the protocol.

- Current chronic, acute, or recurrent bacterial, fungal, or viral (other than HIV)
infections that are serious, in the opinion of the site investigator, and required
systemic therapy within 30 days prior to entry

- History of or active autoimmune disorders including but not limited to inflammatory
bowel diseases, scleroderma, severe psoriasis, myocarditis, uveitis, pneumonitis,
systemic lupus erythematosus, rheumatoid arthritis, optic neuritis, myasthenia
gravis, adrenal insufficiency, hypothyroidism and/or hyperthyroidism, autoimmune
thyroiditis, or sarcoidosis. More information on this criterion is available in the
protocol.

- History of inflammatory disorders of the eye including uveitis (iritis,
endophthalmitis, scleritis, retinitis - including viral or other infectious
retinitis) and chronic or recurrent post-operative inflammation. NOTE: A history of
self-limited conjunctivitis, blepharitis, or hordeolum (stye) are NOT exclusions.

- Previous ocular treatment with silicone oil tamponade (for complex retinal
detachment)

- Intraocular surgery within 90 days prior to entry or the anticipated need for
intraocular surgery during the course of the study

- Intraocular laser or cryotherapy within 90 days prior to entry or the anticipated
need for intraocular laser or cryotherapy during the course of the study

- Evidence on eye exam of active or previous ocular inflammation or uveitis

- Previous history of serious ocular trauma (e.g., penetrating trauma of the eye)

- Severe cataract or other ocular abnormality that precludes adequate examination of
the posterior chamber and fundus

- Active infection or inflammation of the eye within 30 days prior to entry that
requires systemic or topical therapy or, in the opinion of the site investigator,
would complicate on-study evaluation and patient safety. NOTE: A history of
self-limited allergic conjunctivitis is NOT an exclusion. More information on this
criterion is available in the protocol.

- Immune deficiency other than HIV

- Breastfeeding

- Known allergy/sensitivity or any hypersensitivity to components of BMS-936559
(anti-PD-L1) or its formulation

- Active drug or alcohol use or dependence that, in the opinion of the site
investigator, would interfere with adherence to study requirements

- Acute or serious illness, in the opinion of the site investigator, requiring systemic
treatment and/or hospitalization within 30 days prior to entry

- Use of immunomodulators (e.g., interleukins, interferons, cyclosporine), HIV vaccine,
systemic cytotoxic chemotherapy, or investigational therapy within 60 days prior to
study entry. NOTE: Participants receiving stable physiologic glucocorticoid doses,
defined as prednisone less than or equal to 10 mg/day or the equivalent, will not be
excluded. Stable physiologic glucocorticoid doses should not be discontinued for the
duration of the study. In addition, participants receiving inhaled or topical
corticosteroids will not be excluded.

- Intent to use immunomodulators (e.g., IL-2, IL-12, interferons, or tumor necrosis
factor [TNF] modifiers) during the course of the study

- Any vaccination within 30 days prior to screening SCA, pre-entry, or entry.
Individuals who require vaccination will delay screening SCA until 30 days
post-vaccination. Alternatively, vaccinations can occur following the screening SCA,
provided they occur greater than or equal to 30 days prior to pre-entry or entry.

- Current HCV antiviral therapy or participants who have received HCV treatment in the
last 5 years

- Positive tuberculosis (TB) purified protein derivative (PPD) skin test or
interferon-gamma release assay (IGRA) at screening. NOTE: Participants with a prior
positive PPD or IGRA who have not completed prophylaxis treatment will be excluded.

- Women of reproductive potential. More information on this criterion is available in
the protocol.

- History of chronic obstructive pulmonary disease (COPD)

- Type I and type II diabetes mellitus

- Participants weighing less than 50 kg or greater than 200 kg. NOTE: For participants
weighing between 50 kg to 52.9 kg, sites must consult with the A5326 protocol team
prior to enrollment. The allowable blood volume to be drawn in an 8-week period for
these participants may be less than participants weighing greater than or equal to 53
kg.