A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes
| Status: | Completed |
|---|---|
| Conditions: | Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/5/2018 |
| Start Date: | June 4, 2014 |
| End Date: | September 13, 2016 |
A Phase 1 Study To Evaluate The Safety, Tolerability, Immunogenicity, Pharmacokinetics And Pharmacodynamics Of Multiple Ascending Doses Of Pf-06342674 (rn168) In Adults With Type 1 Diabetes
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and
immunogenicity of multiple doses of PF-06342674. Several dose levels will be evaluated.
immunogenicity of multiple doses of PF-06342674. Several dose levels will be evaluated.
Inclusion Criteria:
- Women and men age 18 and older.
- Diagnosis of type 1 diabetes within 2 years of randomization.
- Peak stimulated C-peptide levels ≥ 0.15 ng/mL.
Exclusion Criteria:
- Anticipated ongoing use of diabetes medications other than insulin.
- Evidence or history of diabetic complications with significant end-organ damage.
- Episode of severe hypoglycemia within 60 days of randomization.
- Multiple hospitalizations for diabetic ketoacidosis.
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21
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University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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Univ of Massachusetts Med School As the commonwealth's only public medical school, we take seriously...
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