Strain Imaging in Breast Cancer Patients Receiving Trastuzumab
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/3/2019 |
| Start Date: | September 2014 |
| End Date: | February 14, 2019 |
The purpose of this research study is to evaluate the effects of the chemotherapeutic drug,
Trastuzumab (Herceptin) on the heart. Trastuzumab (Herceptin) is used to treat specific types
of breast cancer and is known to cause weakening of the heart. Unfortunately, little is know
as to why this this happens. The investigators want to identify any factors that may lead to
the early detection, treatment and prevention of the cardiotoxicity (heart problem)
associated with this drug.
Trastuzumab (Herceptin) on the heart. Trastuzumab (Herceptin) is used to treat specific types
of breast cancer and is known to cause weakening of the heart. Unfortunately, little is know
as to why this this happens. The investigators want to identify any factors that may lead to
the early detection, treatment and prevention of the cardiotoxicity (heart problem)
associated with this drug.
As a subject participating in this study the following information will be collected:
complete past medical history including age, height, and weight will be done with each
echocardiogram; blood pressure at clinic visits during treatment with trastuzumab, type of
cancer will be noted, type of chemotherapy, doses of chemotherapy, type and dose of
chemotherapy in the past, type and dose of radiation therapy received, names and doses of
cardiac medications, results of cardiac tests, results of lab tests, family history of heart
disease, and social history which will include risk factors for developing heart disease
including tobacco and alcohol use. This information will be entered into a database for the
investigators to try and detect any factors that may lead to the cardiotoxicity (heart
problem) that may be caused by Trastuzumab (Herceptin).
Any transthoracic echocardiogram (heart ultrasound) ordered will be further evaluated for
special parameters that may help to detect weakening of the heart earlier than a normal
ultrasound. An echocardiogram (heart ultrasound) is when a probe is placed on the chest and
pictures are taken using sound waves and a special camera.
complete past medical history including age, height, and weight will be done with each
echocardiogram; blood pressure at clinic visits during treatment with trastuzumab, type of
cancer will be noted, type of chemotherapy, doses of chemotherapy, type and dose of
chemotherapy in the past, type and dose of radiation therapy received, names and doses of
cardiac medications, results of cardiac tests, results of lab tests, family history of heart
disease, and social history which will include risk factors for developing heart disease
including tobacco and alcohol use. This information will be entered into a database for the
investigators to try and detect any factors that may lead to the cardiotoxicity (heart
problem) that may be caused by Trastuzumab (Herceptin).
Any transthoracic echocardiogram (heart ultrasound) ordered will be further evaluated for
special parameters that may help to detect weakening of the heart earlier than a normal
ultrasound. An echocardiogram (heart ultrasound) is when a probe is placed on the chest and
pictures are taken using sound waves and a special camera.
Inclusion Criteria:
- Age greater than 18 years
- Her 2 positive breast cancer.
- Patients who are currently receiving Trastuzumab (Herceptin).
- Patients who received Trastuzumab (Herceptin) after the formation of the UFHealth
Medical Plaza pharmacy database was initiated.
Exclusion Criteria:
- Age less than 18 years
- Patients who have not received Trastuzumab (Herceptin).
- Patients who received Trastuzumab prior to the formation of the UFHealth Medical Plaza
pharmacy database.
We found this trial at
1
site
Gainesville, Florida 32610
Principal Investigator: Anita D Szady, MD
Phone: 352-273-8933
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