Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome

The proposed study will provide better understanding of the patterns of default mode network
(DMN) dysfunction in comatose state of hepatic encephalopathy, may help to further define
the boundaries of neuronal circuits involve, and will try to assess the prognostic value of
fMRI in reversibility of severe metabolic coma.

(Hepatic Encephalopathy Group)

Inclusion Criteria:

- Patient or legally acceptable representative must understand the purpose and risks of
the study and provide signed and dated informed consent and authorization to use
protected health information (PHI) in accordance with national and local patient
privacy regulations.

- Age 18 or older at the time of informed consent.

- Patients with liver cirrhosis attending the gastroenterology department (inpatient or
outpatient) with hepatic encephalopathy from various causes of liver failure (i.e.
alcoholic, infectious, carcinomatous or toxic).

- The patients will be selected applying Child Pughs score and West Raven
classification for hepatic encephalopathy.

- All patients participating in the study will undergo a full neurological exam, 30 min
routine EEG recording and neuropsychological evaluation along with the f-MRI study.

(Hepatic Encephalopathy Group)

Exclusion Criteria:

- History of alcohol consumption or illicit drug use within past 3 months.

- Patients with underlying psychiatric or neurologic illness (i.e. schizophrenia,
untreated major depressive disorder, epilepsy, neurodegenerative dementia, etc.)
resulting in unrelated to encephalopathy impairment of consciousness and/or
alteration of normal mental capacity.

- Patients after head injury or with advanced pulmonary, renal, or other than liver
failure metabolic disorder (such as severe hypoxia, hypo/hyperglycemia, metabolic
acidosis or alkalosis).

- Patients requiring sedation for MRI.

- Pregnant women.

(Normal Control Group)

Inclusion Criteria:

- Ability to understand the purpose and risks of the study and provide signed and dated
informed consent and authorization to use protected health information (PHI) in
accordance with national and local subject privacy regulations.

- Be age 18 or older at the time of informed consent.

- Subjects must be right handed, be free from any neurological injury, be free from any
neurological diseases, be free from any psychological diseases, have a baseline Blood
pressure < 140/90, not currently be taking any mind altering medications (including
antidepressants, anxiolytics, or opioid/narcotic pain medications), and not have
claustrophobia

(Normal Control Group)

Exclusion Criteria:

- Unwillingness or inability to comply with the requirements of this protocol,
including the presence of any condition (physical, mental, or social) that is likely
to affect the subject's ability to comply with the study protocol.

- History of alcohol consumption 1 week prior to the MRI.

- Illicit drug use within past 3 months.

- Patients requiring sedation for MRI.

- Pregnant women.

- Any other condition, clinical finding, or reason that, in the opinion of the
Investigator, is determined to be unsuitable for enrollment into this study.