Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Status: | Completed |
---|---|
Conditions: | Neurology, Psychiatric |
Therapuetic Areas: | Neurology, Psychiatry / Psychology |
Healthy: | No |
Age Range: | 50 - Any |
Updated: | 4/21/2016 |
Start Date: | June 2013 |
End Date: | February 2016 |
Non Invasive Monitoring of Cerebral Blood Flow During and After Cardiopulmonary Bypass to Assess and Compare for the Presence of Delirium in Post Operative Patients (DELIRIUM)
Cardiac surgery is associated with multiple events and issues that increase risk for adverse
postoperative neurological outcomes including postoperative cognitive dysfunction. The risk
for postoperative delirium is generally thought to result from some previous health factors
added to the susceptibility of the cardiac surgery process.
postoperative neurological outcomes including postoperative cognitive dysfunction. The risk
for postoperative delirium is generally thought to result from some previous health factors
added to the susceptibility of the cardiac surgery process.
Cardiac surgery is associated with multiple perturbations that increase risk for adverse
postoperative neurological outcomes including postoperative cognitive dysfunction. These
same perturbations likely also increase the risk for postoperative delirium although there
are little data that have evaluated this hypothesis.
As the subject is prepared for surgery 2 contact probes will be placed on the forehead to
monitor the rSO2 and cerebral blood flow. This monitor can also measureblood flow velocity
in blood vessels in the forehead.
This will only be done while the subject is on the cardiac bypass machine during the surgery
and end shortly after entering the intensive care unit.Prior to surgery and then once a day
on three of the first four postoperative days, patients will be assessed for the presence
and severity of delirium with brief standard psychological exams. We will compare rSO2 and
CBF changes between patients with and without delirium
postoperative neurological outcomes including postoperative cognitive dysfunction. These
same perturbations likely also increase the risk for postoperative delirium although there
are little data that have evaluated this hypothesis.
As the subject is prepared for surgery 2 contact probes will be placed on the forehead to
monitor the rSO2 and cerebral blood flow. This monitor can also measureblood flow velocity
in blood vessels in the forehead.
This will only be done while the subject is on the cardiac bypass machine during the surgery
and end shortly after entering the intensive care unit.Prior to surgery and then once a day
on three of the first four postoperative days, patients will be assessed for the presence
and severity of delirium with brief standard psychological exams. We will compare rSO2 and
CBF changes between patients with and without delirium
Inclusion Criteria:
- Patients in the study will be 50 or older undergoing elective cardiovascular surgery
using cardiopulmonary bypass.
- Patients who can speak, read and understand the English language.
- Patients who understand the nature of the study and are willing to sign the consent
form
Exclusion Criteria:
- Emergency surgery or patients intubated before surgery and, thus, cannot give
informed consent.
- Patients diagnosed with neurocognitive disorders (e.g. Alzheimer's, Dementia)
- MMSE score greater than 21 Patients taking antipsychotic drugs A history of drug
abuse
- Patients with an implant in the brain underneath the CerOx probes
- Women who are pregnant.
- History of significant, prohibitive skin allergies or reactions-
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