Ultrasound Method to Measure Fibrosis of the Liver in Children
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Gastrointestinal, Gastrointestinal, Hepatitis |
| Therapuetic Areas: | Gastroenterology, Immunology / Infectious Diseases, Other |
| Healthy: | No |
| Age Range: | 5 - 18 |
| Updated: | 4/2/2016 |
| Start Date: | June 2010 |
| End Date: | March 2015 |
| Contact: | Uzma Shah, MD, FAAP |
| Email: | USHAH@partners.org |
| Phone: | 617-726-0319 |
Sonoelastography: Ultrasound Method to Measure Fibrosis of the Liver in Children
HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) provide accurate
quantitative measurements that can be used to stage liver fibrosis in pediatric patients
with chronic liver disease.
Specific Aims:
1. To measure liver stiffness with sonoelastography in adults with suspect diffuse liver
disease who will undergo nonfocal liver biopsy as part of their routine clinical care.
2. To assess the sensitivity and specificity of sonoelastography for the detection and
staging of liver fibrosis.
3. To obtain sonoelastography values of the liver in healthy children (control subjects).
quantitative measurements that can be used to stage liver fibrosis in pediatric patients
with chronic liver disease.
Specific Aims:
1. To measure liver stiffness with sonoelastography in adults with suspect diffuse liver
disease who will undergo nonfocal liver biopsy as part of their routine clinical care.
2. To assess the sensitivity and specificity of sonoelastography for the detection and
staging of liver fibrosis.
3. To obtain sonoelastography values of the liver in healthy children (control subjects).
Inclusion criteria:
- Patients scheduled for random liver biopsy for routine staging of liver fibrosis
- Pediatric patients patients (ages 5-18)
- Girls or boys
- Suspected liver disease
- Consent to participate in the study
Inclusion criteria for Controls:-
- Patients scheduled for ultrasound examination (other than a liver biopsy)
- Pediatric patients (ages 5-18) without known liver disease
- Girls or boys
- No known liver disease
- Consent to participate in the study
Exclusion criteria:
- Pregnancy
- Acute illness/cognitive impairment resulting in inability to cooperate with
ultrasound
- Patients that do not consent to ultrasound guided liver biopsy.
- Contraindications to liver biopsy (e.g. low platelets defined as a platelet count of
less than 50,000, and hemophilia/coagulopathy as an INR higher than 1.5.)
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