S. Aureus Colonization in Atopic Dermatitis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Psoriasis, Dermatology, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 2/2/2017 |
| Start Date: | December 2011 |
| End Date: | December 2017 |
Staphylococcus Aureus Colonization in Atopic Dermatitis
The purpose of this study is to characterize the bacterial strains that colonize children
with atopic dermatitis.
The investigators hypothesize that rectal cultures will be more sensitive than anterior
nares cultures for detecting S. aureus colonization, and that strains of S. aureus
colonizing patients with atopic dermatitis will be resistant to commonly used topical
antibiotic ointments.
with atopic dermatitis.
The investigators hypothesize that rectal cultures will be more sensitive than anterior
nares cultures for detecting S. aureus colonization, and that strains of S. aureus
colonizing patients with atopic dermatitis will be resistant to commonly used topical
antibiotic ointments.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and
eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest
in the most developed nations and predominantly affects children, with 50% of cases arising
in the first year of life, and most others arising in the first 5 years. There is a
well-known increased susceptibility to skin infection with S. aureus in patients with AD,
and such infections are associated with clinical deterioration. While it is routine to
evaluate for S. aureus colonization in the anterior nares, there is recent evidence
suggesting that rectal colonization may be more significant. The significance of
colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no
routine data on the resistance to these agents.
Our aim is to characterize the S. aureus colonization patterns in children with AD,
including site of colonization and antibiotic resistance. We will analyze
routinely-collected skin culture specimens from children with AD seen at our center and
determine antibiotic susceptibility profiles. The significance of colonization site will be
analyzed.
eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest
in the most developed nations and predominantly affects children, with 50% of cases arising
in the first year of life, and most others arising in the first 5 years. There is a
well-known increased susceptibility to skin infection with S. aureus in patients with AD,
and such infections are associated with clinical deterioration. While it is routine to
evaluate for S. aureus colonization in the anterior nares, there is recent evidence
suggesting that rectal colonization may be more significant. The significance of
colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no
routine data on the resistance to these agents.
Our aim is to characterize the S. aureus colonization patterns in children with AD,
including site of colonization and antibiotic resistance. We will analyze
routinely-collected skin culture specimens from children with AD seen at our center and
determine antibiotic susceptibility profiles. The significance of colonization site will be
analyzed.
Inclusion Criteria:
- subjects with a diagnosis of atopic dermatitis seen by the Columbia University
Medical Center department of dermatology
- subjects ages 0 to 18 years
Exclusion Criteria:
- those patients in which a definitive diagnosis of AD cannot be made
- subjects over the age of 18 years old
- subjects with evidence of acute systemic illness
- subjects currently taking systemic antibiotics
- subjects with viral or fungal skin infection
- any individual who declines participation
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