Safety Study Of Tofacitinib Versus Tumor Necrosis Factor (TNF) Inhibitor In Subjects With Rheumatoid Arthritis



Status:Recruiting
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:50 - Any
Updated:4/6/2019
Start Date:March 14, 2014
End Date:March 3, 2020
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

PHASE 3B/4 RANDOMIZED SAFETY ENDPOINT STUDY OF 2 DOSES OF TOFACITINIB IN COMPARISON TO A TUMOR NECROSIS FACTOR (TNF) INHIBITOR IN SUBJECTS WITH RHEUMATOID ARTHRITIS

This post-marketing study is designed to compare the safety of tofacitinib versus TNF
inhibitor with respect to major cardiovascular adverse events and malignancies, excluding
non-melanoma skin cancers when given to subjects with rheumatoid arthritis. Other safety
events, including non-melanoma skin cancers, hepatic events, infections, and efficacy
parameters will be collected and evaluated in the study.


Inclusion Criteria:

- Moderate to severe rheumatoid arthritis

- Taking methotrexate without adequate control of symptoms

- Have at least one cardiovascular risk factor (eg, current smoker, high blood pressure,
high cholesterol levels, diabetes mellitus, history of heart attack, family history of
coronary heart disease, extra-articular RA disease)

Exclusion Criteria:

- Current or recent infection

- Clinically significant laboratory abnormalities

- Pregnancy
We found this trial at
157
sites
Cincinnati Rheumatic Disease Study Group
Cincinnati, Ohio 45219
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Borgess Research Institute
1521 Gull Road Kalamazoo
Kalamazoo, Michigan 49048
269-226-4803
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Advanced Medical Research Center
1690 Dunlawton Ave # 220
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
Harbor UCLA Medical Center
1000 W Carson St
Torrance, California 90502
?
mi
from
Torrance, CA
Click here to add this to my saved trials
Amarillo Center for Clinical Research
Amarillo, Texas 79124
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Arthritis and Rheumatology of GA, P.C.
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Austin Regional Clinic
Austin, Texas 78731
?
mi
from
Austin, TX
Click here to add this to my saved trials
Bronson Healthcare Group - Bronson Internal Medicine and Rheumatology
2845 Capital Avenue Southwest
Battle Creek, Michigan 49015
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
Bronson Healthcare Group
485 East Columbia Avenue
Battle Creek, Michigan 49015
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
University of Alabama at Birmingham (UAB), Arthritis Clinical Intervention Program
Birmingham, Alabama 35294
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Clinical Research Services
Bismarck, North Dakota 58501
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
Dorothy Sander, RPh
Bismarck, North Dakota 58501
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
St. Alexius Medical Center Inpatient Pharmacy
Bismarck, North Dakota 58501
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
RASF Clinical Research Center
Boca Raton, Florida
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
Bay Area Arthritis and Osteoporosis
Brandon, Florida 33511
?
mi
from
Brandon, FL
Click here to add this to my saved trials
Weill Cornell Physicians at Brooklyn Heights
Brooklyn, New York 11201
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Consultorios Reumatologicos Pampa.
C.a.b.a., Buenos Aires
?
mi
from
C.a.b.a.,
Click here to add this to my saved trials
Medical Associates of North Georgia
Canton, Georgia 30114
?
mi
from
Canton, GA
Click here to add this to my saved trials
Trinity Universal Research Associates, Inc
Carrollton, Texas 75007
?
mi
from
Carrollton, TX
Click here to add this to my saved trials
Low Country Rheumatology
Charleston, South Carolina 29406
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Rheumatology Associates
Charleston, South Carolina 29407
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Center for Arthritis and Rheumatic Diseases
Chesapeake, Virginia 23320
?
mi
from
Chesapeake, VA
Click here to add this to my saved trials
Florida Clinical Research Group
Clearwater, Florida 33759
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Arthritis and Rheumatism Associates
612 Druid Road
Clearwater, Florida 33756
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Dr.Robert W. Levin MDOffice of
1831 North Belcher Road
Clearwater, Florida 33765
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Summit Medical Group
Clifton, New Jersey 07012
?
mi
from
Clifton, NJ
Click here to add this to my saved trials
Coeur D'Alene Arthritis Clinic
Coeur D'Alene, Idaho 83814
?
mi
from
Coeur D'Alene, ID
Click here to add this to my saved trials
Arthritis Associates And Osteoporosis Center Of Colorado Springs
Colorado Springs, Colorado 80910
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
Medvin Clinical Research
Covina, California 91723
?
mi
from
Covina, CA
Click here to add this to my saved trials
Klein & Associates, MD, PA
Cumberland, Maryland 21502
?
mi
from
Cumberland, MD
Click here to add this to my saved trials
Pioneer Research Solutions
Cypress, Texas 77429
?
mi
from
Cypress, TX
Click here to add this to my saved trials
Arthritis Centers of Texas
Dallas, Texas
?
mi
from
Dallas, TX
Click here to add this to my saved trials
U.T. Southwestern Medical Center
2201 Inwood Rd
Dallas, Texas 75235
(214) 645-8300
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Harold C. Simmons Comprehensive Cancer Center-University of Texas Southwestern Medical Center
2201 Inwood Road
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
University of Texas Southwestern Medical Center - Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Baylor Scott and White Research Institute / Arthritis Care and Research Center
Dallas, Texas 75231
?
mi
from
Dallas, TX
Click here to add this to my saved trials
STAT Research, Inc.
Dayton, Ohio 45417
?
mi
from
Dayton, OH
Click here to add this to my saved trials
International Medical Research
Daytona Beach, Florida 32117
?
mi
from
Daytona Beach, FL
Click here to add this to my saved trials
Office of Jefrey D. Lieberman, MD, PC
Decatur, Georgia 30033
?
mi
from
Decatur, GA
Click here to add this to my saved trials
Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
?
mi
from
Duncansville, PA
Click here to add this to my saved trials
EmergeOrtho,P.A.
Durham, North Carolina 27704
?
mi
from
Durham, NC
Click here to add this to my saved trials
St. Paul Rheumatology, PA
Eagan, Minnesota 55121
?
mi
from
Eagan, MN
Click here to add this to my saved trials
Med Investigations
Fair Oaks, California 95628
?
mi
from
Fair Oaks, CA
Click here to add this to my saved trials
Phase III Clinical Research
Fall River, Massachusetts 02720
?
mi
from
Fall River, MA
Click here to add this to my saved trials
Centre for Rheumatology, Immunology & Arthritis
Fort Lauderdale, Florida 33334
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
Arthritis Treatment Center
Frederick, Maryland 21702
?
mi
from
Frederick, MD
Click here to add this to my saved trials
Rheumatic Disease Center
Glendale, Wisconsin 53217
?
mi
from
Glendale, WI
Click here to add this to my saved trials
Northwell Health - merge
Great Neck, New York 11021
?
mi
from
Great Neck, NY
Click here to add this to my saved trials
Physician's East
Greenville, North Carolina 27834
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Piedmont Arthritis Clinic, PA
Greenville, South Carolina 29601
?
mi
from
Greenville, SC
Click here to add this to my saved trials
Innovative Clinical Research
7021 Augusta Road
Greenville, South Carolina 29604
?
mi
from
Greenville, SC
Click here to add this to my saved trials
Klein & Associates MD, PA.
Hagerstown, Maryland 21740
?
mi
from
Hagerstown, MD
Click here to add this to my saved trials
PMG Research of Hickory, LLC
Hickory, North Carolina 28602
?
mi
from
Hickory, NC
Click here to add this to my saved trials
Frycare outpatient imaging Center
1781 Tate Boulevard Southeast
Hickory, North Carolina 28602
?
mi
from
Hickory, NC
Click here to add this to my saved trials
CHI St. Vincent Medical Group Hot Springs
Hot Springs, Arkansas 71913
?
mi
from
Hot Springs, AR
Click here to add this to my saved trials
Accurate Clinical Management
Houston, Texas 77004
?
mi
from
Houston, TX
Click here to add this to my saved trials
Rheumatic Disease Clinical Research Center
Houston, Texas 77004
?
mi
from
Houston, TX
Click here to add this to my saved trials
Accurate Clinical Research
Houston, Texas
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston Institute for Clinical Research
Houston, Texas 77024
?
mi
from
Houston, TX
Click here to add this to my saved trials
Accurate Clinical Management
Houston, Texas 77004
?
mi
from
Houston, TX
Click here to add this to my saved trials
Medical Center Research, LLC
Houston, Texas 77089
?
mi
from
Houston, TX
Click here to add this to my saved trials
Talbert Medical Group
Huntington Beach, California 92646
?
mi
from
Huntington Beach, CA
Click here to add this to my saved trials
Rheumatology Associates Of North Alabama, P.C.
Huntsville, Alabama 35801
?
mi
from
Huntsville, AL
Click here to add this to my saved trials
Rheumatology Associates of N. Alabama, PC
Huntsville, Alabama 35801
?
mi
from
Huntsville, AL
Click here to add this to my saved trials
Diagnostic Rheumatology and Research PC
Indianapolis, Indiana 46227
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
West Tennessee Research Institute
Jackson, Tennessee 38305
?
mi
from
Jackson, TN
Click here to add this to my saved trials
University of Florida College of Medicine, Jacksonville - Rheumatology Research
Jacksonville, Florida 32207
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
University of Florida, Rheumatology at ACC
Jacksonville, Florida 32207
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
UF Health-Rheumatology
4555 Hart Expressway
Jacksonville, Florida 32207
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
University of Florida College of Medicine Jacksonville
Jacksonville, Florida 32209
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Arthritis And Rheumatism Associates LLC
Jonesboro, Arkansas 72401
?
mi
from
Jonesboro, AR
Click here to add this to my saved trials
Jasper Clinic, Inc.
Kalamazoo, Michigan 49007
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Borgess Medical Center
1521 Gull Rd
Kalamazoo, Michigan 49048
269) 226-7000
Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Western Michigan University School Of Medicine
300 Portage Street
Kalamazoo, Michigan 49008
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Glacier View Research Institute
Kalispell, Montana 59901
?
mi
from
Kalispell, MT
Click here to add this to my saved trials
Glacier View Research Institute(Regulatory/Administrative)
Kalispell, Montana 59901
?
mi
from
Kalispell, MT
Click here to add this to my saved trials
Kansas City Internal Medicine
Kansas City, Missouri 64114
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
Rheumatology Consultants Pllc
Knoxville, Tennessee 37909
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
University of California, San Diego (UCSD) - Perlman Ambulatory Clinic
La Jolla, California 92093
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
NYU Langone Rheumatology Associates Long Island
Lake Success, New York 11042
?
mi
from
Lake Success, NY
Click here to add this to my saved trials
June D.O. PC
Lansing, Michigan 48910
?
mi
from
Lansing, MI
Click here to add this to my saved trials
University of Nevada School of Medicine
Las Vegas, Nevada
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Steinberg Diagnostics
Las Vegas, Nevada 89109
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Access Health / Davis Group, Ltd.
Las Vegas, Nevada 89128
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Physician Research Collaboration
Lincoln, Nebraska 68512
?
mi
from
Lincoln, NE
Click here to add this to my saved trials
Valerius Medical Group And Research Center Of Greater Long Beach, Inc.
Long Beach, California 90806
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
ProHealth Partners
Long Beach, California 90808
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
University of Southern California (U.S.C.)/ Norris Comprehensive Cancer Center
Los Angeles, California 90033
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Keck Medicine of USC
Los Angeles, California 90033
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Arthritis & Osteoporosis Associates, LLP
Lubbock, Texas 79424
?
mi
from
Lubbock, TX
Click here to add this to my saved trials
Dr. Ramesh C. Gupta MD, Office of
6005 Park Avenue
Memphis, Tennessee 38119
?
mi
from
Memphis, TN
Click here to add this to my saved trials
Center for Diagnostic Imaging
Mendota Heights, Minnesota 55118
?
mi
from
Mendota Heights, MN
Click here to add this to my saved trials
Southwest Rheumatology Research LLC
Mesquite, Texas 75150
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
San Marcus Research Clinic
Miami, Florida 33015
?
mi
from
Miami, FL
Click here to add this to my saved trials
Doctors Research Institute
Miami, Florida 33145
?
mi
from
Miami, FL
Click here to add this to my saved trials
Center for Arthritis and Rheumatic Diseases
Miami, Florida 33173
?
mi
from
Miami, FL
Click here to add this to my saved trials
San Marcus Research Clinic
Miami Lakes, Florida 33014
?
mi
from
Miami Lakes, FL
Click here to add this to my saved trials
Trinity Health Center - Medical Arts
Minot, North Dakota 58701
?
mi
from
Minot, ND
Click here to add this to my saved trials
Arthritis and Diabetes Clinic, Inc
Monroe, Louisiana 71203
?
mi
from
Monroe, LA
Click here to add this to my saved trials
Nashua Rheumatology
Nashua, New Hampshire 03060
?
mi
from
Nashua, NH
Click here to add this to my saved trials
Nashua Rheumatology, SNHHS
17 Prospect Street
Nashua, New Hampshire 03060
?
mi
from
Nashua, NH
Click here to add this to my saved trials