Negative Work Exercise for the Treatment of Knee Arthritis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 50 - 70 |
| Updated: | 9/22/2018 |
| Start Date: | March 2014 |
| End Date: | November 2019 |
Development of a Negative Work Exercise Regimen as an Intervention for Posttraumatic Osteoarthritis of the Knee
The purpose of this study is to develop a negative work exercise regimen as an intervention
for posttraumatic osteoarthritis (PTOA). "Negative work" is the force produced by muscles as
they lengthen, and regularly occurs with common activities such as lowering an object from a
shelf or walking down stairs. In this study, the investigators are examining the
effectiveness of negative work exercise over a 12-week period in older, male, Veterans.
for posttraumatic osteoarthritis (PTOA). "Negative work" is the force produced by muscles as
they lengthen, and regularly occurs with common activities such as lowering an object from a
shelf or walking down stairs. In this study, the investigators are examining the
effectiveness of negative work exercise over a 12-week period in older, male, Veterans.
Purpose: To develop a negative work exercise regimen as an intervention for posttraumatic
osteoarthritis (PTOA). Given that the medical management of chronic PTOA is similar to
idiopathic OA, the investigators propose a randomized, clinical trial to pilot negative work
exercise in Veterans with knee OA as a proof-of-concept study for a subsequent investigation
for people with PTOA.
Research Setting: DC VAMC, Physical Medicine & Rehabilitation Laboratory
Participants: Men between the ages of 50 and 70 years with a history of bilateral knee
osteoarthritis will be consecutively recruited from the DC VAMC Rheumatology Service,
Geriatrics Service, and Primary Care Medical Service.
Implications/Significance: The use of negative work exercise to enhance the force attenuation
properties of muscle is an innovative approach to the treatment of OA and PTOA, and
represents a significant departure from previous rehabilitation studies concerning arthritis.
Use of a negative work paradigm may prove to be beneficial for older Veterans with OA and
active military personnel with PTOA since similar muscle mechanics are involved in the energy
absorption at the knee joint during gait. Despite the functional importance of lengthening
muscle actions in protecting weight-bearing joints affected by arthritis, the authors are not
aware of a study that involves the sole use of a negative work intervention for OA or PTOA.
Addressing the aims of this proposal would lay the ground work needed to justify larger
clinical trials featuring the negative work paradigm for soldiers with PTOA.
osteoarthritis (PTOA). Given that the medical management of chronic PTOA is similar to
idiopathic OA, the investigators propose a randomized, clinical trial to pilot negative work
exercise in Veterans with knee OA as a proof-of-concept study for a subsequent investigation
for people with PTOA.
Research Setting: DC VAMC, Physical Medicine & Rehabilitation Laboratory
Participants: Men between the ages of 50 and 70 years with a history of bilateral knee
osteoarthritis will be consecutively recruited from the DC VAMC Rheumatology Service,
Geriatrics Service, and Primary Care Medical Service.
Implications/Significance: The use of negative work exercise to enhance the force attenuation
properties of muscle is an innovative approach to the treatment of OA and PTOA, and
represents a significant departure from previous rehabilitation studies concerning arthritis.
Use of a negative work paradigm may prove to be beneficial for older Veterans with OA and
active military personnel with PTOA since similar muscle mechanics are involved in the energy
absorption at the knee joint during gait. Despite the functional importance of lengthening
muscle actions in protecting weight-bearing joints affected by arthritis, the authors are not
aware of a study that involves the sole use of a negative work intervention for OA or PTOA.
Addressing the aims of this proposal would lay the ground work needed to justify larger
clinical trials featuring the negative work paradigm for soldiers with PTOA.
Inclusion Criteria:
- Adult men 50 y.o. 70 years old will be recruited for this proposed study.
- Participant inclusion criteria includes having bilateral knee OA (Kellgren-Lawrence
Grade 2 or 3) and sedentary (e.g., have not engaged in 3 exercise sessions per week
for 3 consecutive months).
- Gait aides and orthoses will not preclude participation in this study.
Exclusion Criteria:
- Exclusion criteria include uncontrolled cardiovascular disease, non-ambulatory status,
neurogenic weakness, knee extensor and flexor manual muscle test < 3 out of 5, lower
extremity amputation, and current participation in a supervised exercise program.
- In addition, major surgical procedures within the last six months, unstable joints,
endocrine or metabolic disorders that result in excessive fatigue or muscle weakness,
or use of medications that may impair exercise tolerance would also preclude
participation in this study.
We found this trial at
1
site
Washington, District of Columbia 20422
Principal Investigator: Michael Harris-Love, DSc
Phone: 202-745-8000
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