A Study to Compare the Oral Bioavailability of Single Doses of Two Vapendavir Drug Formulations in Healthy Volunteers

Inclusion Criteria:

- Must be male or female between 18 and 55 years of age (inclusive) with BMI between 18
and 30 kg/m2 (inclusive), and weight ≥50 kg at the time of screening

- Capable of giving written informed consent

- Subject is able to understand and comply with the protocol requirements, instructions
and restrictions

- Healthy on the basis of physical examination, medical history, medication usage, VS,
ECGs, and clinical laboratory tests

- Female subjects must be of non-childbearing potential

- Male subjects must agree to use a double barrier method of birth control

Exclusion Criteria:

- Positive results for Hepatitis B, Hepatitis C, or HIV

- Frequent use of tobacco products, including cigarettes, cigars, chewing tobacco

- A medical history of significant hematological, gastrointestinal, respiratory, renal,
hepatic, cerebrovascular, immunologic, psychiatric or cardiovascular disease or event;
Current or recent respiratory infection

- Presence or history of significant allergy

- Clinically significant abnormalities noted on ECG

- Screening vital signs representing sustained elevated blood pressure

- Presence of significant gastrointestinal abnormalities

- Safety laboratory abnormalities noted at screening which are clinically significant

- Current or defined history of abuse of alcohol or illicit drugs

- A positive pregnancy test at screening

- Poor vein access or fear of venipuncture or sight of blood