Pilot Study to Test Dietary Fat Delivery
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | June 2014 |
| End Date: | February 2017 |
| Contact: | Elizabeth J Parks, PhD |
| Email: | parksej@missouri.edu |
| Phone: | 573-822-5864 |
The average American diet consumed by a significant proportion of the adult population,
supplies excessive calories and large amounts of saturated fat. Saturated fats can be
cleared and used in skeletal muscle, but in obese individuals, biomarkers of saturated fat
are found in the blood, along with markers of poor muscle metabolism.
Both fats and amino acids are processed by the same metabolic pathways in muscle, and the
investigators hypothesize that meals with greater amounts of saturated fat slow muscle
metabolism. A better understanding of the interaction of these to metabolites will allow for
the development of future medications to treat muscle loss in sick individuals and the
elderly.
supplies excessive calories and large amounts of saturated fat. Saturated fats can be
cleared and used in skeletal muscle, but in obese individuals, biomarkers of saturated fat
are found in the blood, along with markers of poor muscle metabolism.
Both fats and amino acids are processed by the same metabolic pathways in muscle, and the
investigators hypothesize that meals with greater amounts of saturated fat slow muscle
metabolism. A better understanding of the interaction of these to metabolites will allow for
the development of future medications to treat muscle loss in sick individuals and the
elderly.
This study includes two parts, a baseline study and a three-week dietary study. The baseline
study will be performed to test how the body absorbs and stores meal fat after a meal. In
the three-week dietary study, the subjects will consume only the meals provided by the
investigators for three weeks before the tests, and then participate in a hospital stay. The
three-week dietary study is to test the chronic effect of a high fat diet on how body
absorbs and stores the fat.
study will be performed to test how the body absorbs and stores meal fat after a meal. In
the three-week dietary study, the subjects will consume only the meals provided by the
investigators for three weeks before the tests, and then participate in a hospital stay. The
three-week dietary study is to test the chronic effect of a high fat diet on how body
absorbs and stores the fat.
Inclusion Criteria:
1. Lean/insulin sensitive (n=10, BMI ≤ 24 kg/m2 and glucose infusion > 4.0 mg/min))
2. Overweight/obese insulin resistant (n=10, BMI 26-35 and glucose infusion < 4.0
mg/min)
3. 30-50 years of age
4. Men and pre-menopausal women
Exclusion Criteria:
1. Insulin resistance is defined by insulin clamp as the rate of glucose infusion ≤ 4.0
mg/min.
2. BMI over 35 kg/m2
3. Abnormal thyroid function, kidney or liver disease
4. Uncontrolled hypertension, or occasional or regular smoker, use of medications or
supplements that interfere with lipid, protein, or carbohydrate metabolism
5. Pregnancy (urine test), breast feeding an infant, or anemia
6. Alcohol intake: Males >140 g/week, Females > 70 g/week.
7. Fasting plasma triglycerides >300 mg/dL. Extreme hypertriglyceridemia could be due to
either elevations in very low-density lipoproteins or chylomicrons, either of which
would impair our ability to resolve dietary metabolic processes.
8. Need to consume acetaminophen-containing medications on a regular basis.
We found this trial at
1
site
Columbia, Missouri 65211
(573) 882-2121
Principal Investigator: Elizabeth J Parks, PhD
Phone: 573-884-1708
University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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