Probing the Cannabinoid System in Individuals With a Family History of Psychosis
| Status: | Recruiting |
|---|---|
| Conditions: | Schizophrenia, Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 6/8/2018 |
| Start Date: | January 2014 |
| End Date: | April 2019 |
| Contact: | Christina Luddy, BS |
| Email: | christina.luddy@yale.edu |
| Phone: | 203-932-5711 |
The overall purpose of this study is to determine whether a family history of psychosis is
associated with an altered cannabinoid system. This will be tested by studying individuals
with and without a family history of psychosis and comparing their responses to delta
9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that
compared to controls with no family history of psychoses, individuals with a family history
of psychoses will have an altered response to THC.
associated with an altered cannabinoid system. This will be tested by studying individuals
with and without a family history of psychosis and comparing their responses to delta
9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that
compared to controls with no family history of psychoses, individuals with a family history
of psychoses will have an altered response to THC.
Inclusion Criteria FHP:
- Exposure to cannabis at least once in their lifetime
- Medically and psychiatrically healthy based on screening
- Having one relative with a confirmed psychotic disorder
Exclusion Criteria FHP:
- Current or lifetime major DSM-IV Axis I disorder
- Current or lifetime treatment (at least 6 months) with psychotropic medications for
major psychiatric or neurological illness
- Major or unstable medical illness that might impact safety of the subject in the study
- Cannabis naive
- IQ less than 85
- Less than a high school diploma or its educational equivalent
- Pregnancy or lactation
- Major current or recent (<6 weeks) psychosocial stressors.
Inclusion Criteria FHN :
- Exposure to cannabis at least once in their lifetime
- Medically and psychiatrically healthy based on screening
Exclusion Criteria FHN:
- Having a family member with psychosis
- Current or lifetime major DSM-IV Axis I disorder
- Current or lifetime treatment (at least 6 months) with psychotropic medications for
major psychiatric or neurological illness
- Major or unstable medical illness that might impact safety of the subject in the study
- Cannabis naive
- IQ less than 85
- Less than a high school diploma or its educational equivalent
- Pregnancy or lactation
- Major current or recent (<6 weeks) psychosocial stressors.
We found this trial at
1
site
950 Campbell Ave
West Haven, Connecticut 06516
West Haven, Connecticut 06516
(203) 932-5711
Principal Investigator: Mohini Ranganathan, MD
Phone: 203-932-5711
VA Connecticut Healthcare System VA Connecticut encompasses an inpatient facility and Ambulatory Care Center in...
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