Omega-3 Fatty Acids to Combat Sarcopenia
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 4/21/2016 |
| Start Date: | March 2014 |
| End Date: | July 2015 |
The purpose of this study is to determine how omega-3 fatty acids influence muscle protein
metabolism and mitochondrial physiology in the context of human aging.
metabolism and mitochondrial physiology in the context of human aging.
Inclusion Criteria:
- Age 18-35 or 65-85 years
Exclusion Criteria:
1. Current use of omega-3 nutritional supplements
2. Fasting plasma glucose ≥126 mg/dL
3. Active coronary artery disease
4. Participation in structured exercise (>3 times per week for 30 minutes or longer)
5. Smoking
6. Medications known to affect muscle metabolism (e.g., beta blockers, corticosteroids,
tricyclic-antidepressants, benzodiazepines, opiates, barbiturates, anticoagulants)
7. Renal failure (serum creatinine > 1.5mg/dl)
8. Chronic active liver disease (Bilirubin > 17mmol/L, AST>144IU/L, or ALT>165IU/L)
9. Anti-coagulant therapy (warfarin/heparin)
10. INR >3
11. Use of systemic glucocorticoids
12. Chronic use of NSAIDS or aspirin
13. Pregnancy or breastfeeding
14. Alcohol consumption greater than 2 glasses/day
15. Hypothyroidism
16. Fish or shellfish allergy
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