A Study Evaluating the Efficacy and Safety of Lebrikizumab in Adult Patients With Mild to Moderate Asthma

Inclusion Criteria:

- Age 18-75 years old at study start

- Asthma diagnosis for >/= 12 months prior to study start

- Bronchodilator response at screening

- Pre-bronchodilator FEV1 of 60% - 85% predicted at both screening visits 2 and 3

- No other clinically significant lung disease as confirmed by chest X-ray or computed
tomography (CT) scan

- Stable and symptomatic asthma during the screening period

- Use of effective contraception, as defined by the protocol, until 24 weeks after the
last dose

Exclusion Criteria:

- Maintenance of corticosteroid therapy, defined as daily or alternate-day oral
corticosteroid maintenance therapy within 3 months prior to study start

- Treatment with systemic or inhaled corticosteroids within 4 weeks prior to study
start or during the screening period for any reason, including an acute exacerbation
event

- Treatment with a leukotriene receptor antagonist (LTRA), long-acting beta-agonist
(LABA) long-acting muscarinic antagonist (LAMA), zileuton, roflumilast, or
theophylline within 2 weeks prior to study start

- Documented prior treatment failure with Montelukast

- Treatment with intra-articular corticosteroids within 4 weeks prior to study start or
during the screening period or anticipated need for intra articular corticosteroids
during the course of the study

- Any infection requiring hospital, IV or IM antibiotic treatment or any respiratory
infection within 4 weeks of study start. Any infection requiring oral antibiotic
treatment within 2 weeks of study start, or any parasitic infection within 6 months
of study start

- Clinically significant abnormality found during screening or clinically significant
medical disease that is uncontrolled despite treatment that is likely, in the opinion
of the investigator, to impact the patient's ability to participate in the study, or
impact the study assessments

- History of interstitial lung disease, chronic obstructive pulmonary disease (COPD),
or other clinically significant lung disease other than asthma

- History of alcohol or drug abuse that would impair or risk the patient's full
participation in the study, in the opinion of the investigator

- Current or history of smoking (> 10 pack-years), or unwillingness to abstain from
smoking for the duration of the study

- Past and/or current use of any anti-IL-13 or anti- IL4/IL-13 therapy, including
lebrikizumab

- Use of a licensed or investigational monoclonal antibody other than anti IL-13 or
anti-IL-4/IL-13, including, but not limited to, omalizumab, anti-IL-5, or anti IL-17,
within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during
screening

- Use of a systemic immunomodulatory or immunosuppressive therapy within 3 months or 5
drug half-lives prior to study start or during screening

- Use of other investigational therapy within 4 weeks or 5 drug half-lives prior to
study start (whichever is longer) or during screening

- Initiation of or change in allergen immunotherapy within 3 months prior to study
start or during screening

- Receipt of a live attenuated vaccine within 4 weeks prior to study start of during
screening

- Pregnancy or breast feeding

- Body mass index > 38 kg/m2

- Body weight < 40 kg

- History of bronchial thermoplasty