Skeletal Muscle Perfusion With LVAD
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 8/25/2018 |
| Start Date: | February 1, 2014 |
| End Date: | December 2019 |
| Contact: | Jonathan R Lindner, MD |
| Email: | lindnerj@ohsu.edu |
| Phone: | 503 494-8750 |
Advanced heart failure (when the heart pump fails) is associated with symptoms such as
shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of
the pump, however abnormal regulation of blood flow to the muscles of the body is also a
potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate
for patients with failing hearts either as a bridge to heart transplant or as long term
therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in
the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion
is altered in heart failure patients before and after implantation of an LVAD could provide
further insight into the beneficial effects of this therapy.
Specific Aims:
1. To evaluate skeletal muscle and heart perfusion studies before and after LVAD
implantation
2. To compare functional status with degree of skeletal muscle perfusion.
shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of
the pump, however abnormal regulation of blood flow to the muscles of the body is also a
potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate
for patients with failing hearts either as a bridge to heart transplant or as long term
therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in
the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion
is altered in heart failure patients before and after implantation of an LVAD could provide
further insight into the beneficial effects of this therapy.
Specific Aims:
1. To evaluate skeletal muscle and heart perfusion studies before and after LVAD
implantation
2. To compare functional status with degree of skeletal muscle perfusion.
Methods:
Thirty patients deemed to be candidates for LVAD from either outpatient heart failure clinic
or inpatient cardiology service will be studies. Skeletal muscle perfusion imaging using
standard of care ultrasound technology will be performed prior to LVAD implant and then 3
months post implant. Functional status by six minute walk test and specialized stress test
will be assessed at 3 months post implant.
Thirty patients deemed to be candidates for LVAD from either outpatient heart failure clinic
or inpatient cardiology service will be studies. Skeletal muscle perfusion imaging using
standard of care ultrasound technology will be performed prior to LVAD implant and then 3
months post implant. Functional status by six minute walk test and specialized stress test
will be assessed at 3 months post implant.
Inclusion Criteria:
- patients deemed to be candidates for a LVAD
Exclusion Criteria:
- severe peripheral artery disease
- skeletal muscle disorder
- severe congenital heart disease
- pregnancy
- patients <18 yo
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Principal Investigator: Jonathan R Lindner, MD
Phone: 503-494-8750
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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