Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Hospital, Lymphoma |
| Therapuetic Areas: | Oncology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/20/2018 |
| Start Date: | April 2014 |
| End Date: | April 2019 |
This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma
associated heart disease compared to a stress echocardiogram. By doing both stress
echocardiography and cardiac MRI, we will compare the ability of the two tests to detect
heart disease.
associated heart disease compared to a stress echocardiogram. By doing both stress
echocardiography and cardiac MRI, we will compare the ability of the two tests to detect
heart disease.
Inclusion Criteria:
- Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering
Cancer Center.
- Age ≥ 18 years
- Treatment for HL that included mediastinal RT at initial diagnosis or relapse.
- ≥ 5 years from last HL treatment.
Exclusion Criteria:
- Primary HL diagnosis prior to 1980.
- Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary
malignant neoplasm.
- Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization,
angiographic obstructive CAD, or decreased LV function [EF < 55%] during prior
clinical care).
- Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other
implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to
gadolinium, advanced renal insufficiency as defined by glomerular filtration rate <30
ml/min/1.73m^2).
- Contraindication to exercise stress testing other than the above (i.e. unstable angina
or severe valvular stenosis).
We found this trial at
1
site
1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: Matthew Matasar, MD
Phone: 212-639-8889
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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