The Effects of Rifampin on the Pharmacokinetics of Rosuvastatin

Inclusion Criteria:

- Healthy Asian volunteers of Han-Chinese/Japanese/Korean descent whose parents and
grandparents are Han-Chinese/ Japanese/ Korean.

- Healthy Caucasian volunteers of White/Caucasian/European-born descent whose parents
and grandparents are White/Caucasian/European.

- Male or female, ages 18-65 years old, with no current medical conditions or active
diagnoses as determined by the study doctor based on history, physical exam, and
laboratory evaluations.

- Subjects who take no other medications two weeks prior to the study and during the
time course of the study including prescription medications, over-the-counter
medications, dietary supplements, or drugs of abuse.

- Subjects with the following genotype: SLCO1B1*1a and ABCG2 421CC.

- Subjects able to maintain adequate birth control during the study independent of
hormonal contraceptive use.

- Subjects able to abstain from grapefruit, grapefruit juice, oranges, orange juice,
caffeinated beverages and/or alcoholic beverages from 7am the day before the study to
completion of that study day.

- Participants determined to have normal liver and kidney function as measured at
baseline

- BMI between 18.0 - 30 kg/m2

- Subjects capable of fasting from food and beverages at least 8 hours prior to
medication dosing.

- Be able to read, speak, and understand English.

- Subjects capable of providing informed consent and completing the requirements of the
study.

Exclusion Criteria:

- Subjects with active medical problems

- Subjects on chronic prescription or OTC medication that cannot be stopped 2 weeks
prior to and during the study.

- Subjects incapable of multiple blood draws (HCT < 30mg/dL)

- Subjects with a history of rhabdomyolysis

- Subjects with a history of drug-related myalgias

- Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias

- Subjects with a history of GI bleed or peptic ulcer disease

- Subjects who smoke tobacco or have ongoing alcohol or illegal drug use

- Subjects who are pregnant, lactating, or trying to conceive during the study period

- Subjects allergic to rosuvastatin or rifampin or any known component of the
medications

- Anyone who in the opinion of the study investigators is unable to do the study