Dovitinib Lactate in Treating Patients With Pancreatic Neuroendocrine Tumors

PRIMARY OBJECTIVES:

I. To evaluate the efficacy of dovitinib (dovitinib lactate) in patients with progressive
well-differentiated neuroendocrine tumors of the pancreas (PNETs) in reference to 6-month
progression free survival (PFS) historical-controlled patients and in two cohorts defined by
prior vascular endothelial growth factor (VEGF)-inhibitor therapy (Cohort 1 - no prior VEGF,
Cohort 2 - prior VEGF).

SECONDARY OBJECTIVES:

I. To determine the safety of dovitinib in patients with progressive well-differentiated
PNETs.

II. To evaluate time to treatment failure, time to progression, and overall survival.

III. To evaluate radiographic and biochemical response rates.

TERTIARY OBJECTIVES:

I. To assess the pharmacodynamic effect of dovitinib on plasma biomarkers by measuring
concentrations of circulating growth factors and soluble receptors (e.g. basic fibroblast
growth factor [bFGF], VEGF, placental growth factor [PLGF], soluble VEGF receptor 1
(sVEGFR1) and 2, collagen IV, fibroblast growth factor 23 [FGF23]).

II. Archival tissue collected from patients prior to registration will be banked to later
analyze baseline expression of potential biomarkers (e.g., bFGF, FGFR).

OUTLINE:

Patients receive dovitinib lactate orally (PO) on days 1-5, 8-12, 15-19, and 22-26. Courses
repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 2 months for 6 months,
every 3 months for 6 months, and then periodically for 2 years.

Inclusion Criteria:

- Histologic diagnosis of a well- to moderately differentiated PNET (low-intermediate
grade); NOTE: pathology report should state one of the following: low-grade,
intermediate grade, moderately- or well-differentiated NET, pancreatic NET (or
neuroendocrine carcinoma of the pancreas); patients who have tumors with a Ki67 of 20
% - 30 % are eligible if the pathologist determines the tumor has the appearance of a
well- to moderately differentiated neuroendocrine tumor

- Documented radiological evidence for disease progression (measurable or
nonmeasurable) =< 12 months prior to enrollment; NOTE: if the patient has had
previous radiation to the marker lesion(s), there must be evidence of progression
since the radiation; at least one measurable lesion as per Response Evaluation
Criteria In Solid Tumors (RECIST)

- Disease that is currently not amenable to surgery, radiation, or combined modality
therapy with curative intent

- COHORT 2 ONLY: Prior treatment with a VEGF inhibitor (e.g. sunitinib, bevacizumab,
sorafenib or other dedicated VEGF inhibitor)

- Recovered from adverse events (to grade 1 or less toxicity according to Common
Terminology Criteria for Adverse Events [CTCAE] 4.0) due to agents administered
previously; NOTE: chemotherapy-induced alopecia and grade 2 neuropathy are acceptable

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Absolute neutrophil count (ANC) >= 1.5 x 10^9/L

- Platelets >= 100 x 10^9/L

- Hemoglobin (Hgb) > 9 g/dL

- Serum total bilirubin =< 1.5 x upper limit of normal (ULN)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3.0 x ULN

- Serum creatinine =< 1.5 x ULN

- Provide informed written consent

- Negative pregnancy test done =< 14 days prior to registration, for women of
childbearing potential only

- Willing to return to an Academic and Community Cancer Research United (ACCRU)
enrolling institution for follow-up (i.e., active monitoring, which includes active
treatment and observation)

- Willing to provide mandatory blood samples for correlative research purposes

Exclusion Criteria:

- Clinical evidence for brain metastases (including carcinomatous meningitis) at
baseline (may require imaging assessment, e.g. computed tomography [CT] or magnetic
resonance imaging [MRI], for certain patient population), with the exception of those
subjects who have previously-treated central nervous system (CNS) metastases (surgery
± radiotherapy, radiosurgery, or gamma knife) and who meet both of the following
criteria: a) are asymptomatic and b) have had no requirement for steroids or enzyme-
inducing anticonvulsants within 6 months prior to study entry

- Participated in a prior anticancer investigational study =< 30 days prior to
enrollment, or =< 5 half-lives of the anticancer investigational product, whichever
is longer (treatment with somatostatin analogue [SSTa] while on dovitinib is allowed
provided patient's tumor has progressed on therapy prior to initiating dovitinib
treatment)

- COHORT 1 ONLY: Prior treatment with a VEGF inhibitor (e.g. sunitinib, bevacizumab,
sorafenib or other dedicated VEGF inhibitor)

- Liver-directed therapy (hepatic artery chemoembolization [HACE], hepatic artery
embolization [HAE], selective internal radiation therapy [SIRT]) or peptide receptor
radionuclide therapy (PRRT) =< 56 days of first dose of study drug

- Another primary malignancy =< 3 years prior to starting study treatment, with the
exception of adequately treated basal cell carcinoma, squamous cell carcinoma or
other non-melanomatous skin cancer, or in-situ carcinoma of the uterine cervix

- Received the last administration of an anticancer targeted small molecule therapy
(e.g. sunitinib, sorafenib, pazopanib, axitinib, everolimus, temsirolimus,
ridaforolimus) =< 14 days prior to study registration or have not recovered from the
side effects of such therapy

- Received the last administration of an anticancer monoclonal antibody, immunotherapy,
hormonal therapy, or chemotherapy (except nitrosoureas and mitomycin-C) =< 28 days
prior to study registration or who have not recovered from the side effects of such
therapy

- Received the last administration of nitrosourea or mitomycin-C =< 42 days prior to
study registration, or who have not recovered from the side effects of such therapy

- Radiotherapy (external beam or CyberKnife) =< 28 days prior to starting study drug,
or =< 14 days prior to study registration in the case of localized radiotherapy (e.g.
for analgesic purpose or for lytic lesions at risk of fracture), or who have not
recovered from radiotherapy toxicities

- Undergone major surgery (e.g. intra-thoracic, intra-abdominal or intra-pelvic), open
biopsy or significant traumatic injury =< 28 days prior to study registration, or had
minor procedures, percutaneous biopsies or placement of vascular access device =< 7
days prior to study registration, or have not recovered from side effects of such
procedure or injury

- History of pulmonary embolism (PE), or untreated deep venous thrombosis (DVT) =< 180
days

- Impaired cardiac function or clinically significant cardiac diseases, including any
of the following:

- History or presence of serious uncontrolled ventricular arrhythmias

- Clinically significant resting bradycardia

- Ongoing cardiac dysrhythmias, atrial fibrillation, or prolongation of corrected
QTc interval to > 480 msec

• * Left ventricular ejection fraction (LVEF) assessed by 2-dimensional (2-D)
echocardiogram (ECHO) < 50% or lower limit of normal (whichever is the higher),
or 2-D multiple gated acquisition scan (MUGA) < 45% or lower limit of normal
(whichever is the higher)

- Any of the following =< 180 days prior to starting study drug: myocardial
infarction (MI), severe/unstable angina, coronary artery bypass graft (CABG),
congestive heart failure (CHF), cerebrovascular accident (CVA), transient
ischemic attack (TIA)

- Uncontrolled hypertension defined by a systolic blood pressure (SBP) >= 160 mm
Hg and/or diastolic (D)BP >= 100 mm Hg, with or without anti-hypertensive
medication(s); initiation or adjustment of antihypertensive medication(s) is
allowed prior to study entry

- Impairment of gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of dovitinib (e.g. ulcerative diseases, uncontrolled nausea,
vomiting, diarrhea, malabsorption syndrome, or gastric or small bowel resection)

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 28 days prior to registration

- No clinically significant gastrointestinal abnormalities that may increase the risk
of gastrointestinal bleeding within 28 days prior to registration including, but not
limited to:

- Active peptic ulcer

- Known endoluminal metastatic lesion(s) with history of bleeding

- Active inflammatory bowel disease (e.g. ulcerative colitis, Crohn's Disease), or
other gastrointestinal conditions with increased risk of perforation

- No evidence of active bleeding, bleeding diathesis, or hemoptysis (>= ½ teaspoon of
red blood) within 8 weeks of registration

- Immunocompromised patients and patients known to be human immunodeficiency virus
(HIV) positive and currently receiving antiretroviral therapy (HIV testing not
required); NOTE: patients known to be HIV positive, but without clinical evidence of
an immunocompromised state (cluster of differentiation [CD]4 > 200, viral load
undetectable, on antiretroviral therapy), are eligible for this trial

- Currently receiving antiplatelet therapy of prasugrel or clopidogrel, or full dose
anticoagulation treatment with therapeutic doses of warfarin; Note: treatment with
low doses of warfarin (e.g., =< 2 mg/day ) for line patency allowed; also, low
molecular weight heparins, fondaparinux, antiaggregation agents (e.g., eptifibatide,
epoprostenol, dipyridamole) or locally accepted low doses of acetylsalicylic acid (up
to 100 mg daily) may be administered concomitantly with dovitinib with caution

- Other concurrent severe and/or uncontrolled concomitant medical conditions (e.g.
active or uncontrolled infection, uncontrolled diabetes) that could cause
unacceptable safety risks or compromise compliance with the protocol

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive human chorionic gonadotropin (hCG) laboratory test

- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant, unless they are using highly effective methods of contraception
(defined below); highly effective contraception must be used by both sexes (female
patients and their male partners) during study treatment and for 30 days after the
last dose of study medication; highly effective contraception methods include:

- Total abstinence (when this is in line with the preferred and usual lifestyle of
the subject); periodic abstinence (e.g., calendar, ovulation, symptothermal,
post-ovulation methods) and withdrawal are not acceptable methods of
contraception

- Female sterilization (have had surgical bilateral oophorectomy with or without
hysterectomy) or tubal ligation at least six weeks before taking study
treatment; in case of oophorectomy alone, only when the reproductive status of
the woman has been confirmed by follow up hormone level assessment

- Combination of the following:

- Placement of an intrauterine device (IUD) or intrauterine system (IUS)

- Barrier methods of contraception: condom or occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal
suppository

- Oral, implantable, or injectable hormone contraceptives are not considered effective
for this study

- Women of child-bearing potential (sexually mature women) who have not undergone a
hysterectomy or who have not been naturally postmenopausal for at least 12
consecutive months (i.e., who has had menses any time in the preceding 12 consecutive
months), must have a negative serum pregnancy test =< 14 days prior to starting study
drug

- Fertile males not willing to use contraception; fertile males must use condom with
spermicide; highly effective contraception, as defined above, must be used by both
sexes (male patients and their female partners) during study treatment and for 90
days after the last dose of study medication and should not father a child in this
period; a condom is required to be used also by vasectomized men

- Unwilling or unable to comply with the protocol

- Co-morbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the patient inappropriate for entry into
this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens

- Currently receiving any other investigational agent which would be considered as a
treatment for the primary neoplasm