Randomized, Double-blind, Placebo Controlled, Multi-center and Tolerability of RBP-7000 in Schizophrenia Patients

Inclusion Criteria:

- Males and females between the ages of 18 to 55 years, inclusive

- Diagnosis of schizophrenia as defined by Diagnostic and Statistical Manual, Edition 4,
text revision (DSM-IV-TR) criteria

- Subjects who are deemed "valid" by the State, Assessability, Face, Ecological, and
Rule (SAFER) interview

- Subjects who are otherwise healthy on the basis of their physical examination

Exclusion Criteria:

- Subjects who have an improvement in their total Positive and Negative Syndrome Scale
(PANSS) score of 20% or greater between the initial screening visit and the first day
of treatment.

- Subjects taking daily oral risperidone at a dose ≥ 6 mg/day

- Subjects who have received a depot antipsychotic within 120 days of screen

- Subjects with treatment resistant schizophrenia, as judged by the investigator, who
have been treated with antipsychotics for adequate durations and with adequate
dosages.