Observational Study of Keratoconus and Post-keratoplasty Eyes
| Status: | Completed |
|---|---|
| Conditions: | Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 4/17/2018 |
| Start Date: | June 2011 |
| End Date: | August 31, 2017 |
A prospective observational study on keratoconus and post-keratoplasty will be conducted. We
will enroll 50 subjects in each of 3 groups: keratoconus, post-PK, and post-DSAEK. The
Optovue anterior segment OCT prototype will be used to perform 3-D corneal scans. These scans
will be used to measure corneal thickness (pachymetry), corneal topography (anterior and
posterior) and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be
used when they become available. A comprehensive eye examination, Placido-ring corneal
topography, ultrasound pachymetry, and Scheimpflug camera imagery, will be performed for
comparison. In some post-PK and post-DSAEK cases, vision will be primarily affected by
regular astigmatism, myopia, or hyperopia, rather than HOA. These cases can be corrected by
standard PRK (not OCT guided) with adjunctive mitomycin C treatment to prevent haze
formation.107, 108 In these cases PRK will be performed according to the standard of care and
will not be a part of the study protocol. The postoperative results will be observed at the
3-4 month visit with UCVA, manifest refraction, BSCVA, OCT scanning, Placido topography,
ultrasound pachymetry, and Scheimpflug camera imagery
will enroll 50 subjects in each of 3 groups: keratoconus, post-PK, and post-DSAEK. The
Optovue anterior segment OCT prototype will be used to perform 3-D corneal scans. These scans
will be used to measure corneal thickness (pachymetry), corneal topography (anterior and
posterior) and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be
used when they become available. A comprehensive eye examination, Placido-ring corneal
topography, ultrasound pachymetry, and Scheimpflug camera imagery, will be performed for
comparison. In some post-PK and post-DSAEK cases, vision will be primarily affected by
regular astigmatism, myopia, or hyperopia, rather than HOA. These cases can be corrected by
standard PRK (not OCT guided) with adjunctive mitomycin C treatment to prevent haze
formation.107, 108 In these cases PRK will be performed according to the standard of care and
will not be a part of the study protocol. The postoperative results will be observed at the
3-4 month visit with UCVA, manifest refraction, BSCVA, OCT scanning, Placido topography,
ultrasound pachymetry, and Scheimpflug camera imagery
Inclusion Criteria:
• Adults (18 & older) with keratoconus, keratoplasty, DSAEK procedures
Exclusion Criteria:
- Inability to give informed consent.
- Inability to maintain stable fixation for OCT imaging.
- Inability to commit to required visits to complete the study.
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