A Study of LY2409021 in Participants With Type 2 Diabetes Mellitus



Status:Terminated
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 79
Updated:4/26/2018
Start Date:April 2014
End Date:September 2015

Use our guide to learn which trials are right for you!

A Phase 2, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of LY2409021 Compared to Sitagliptin in Subjects With Type 2 Diabetes Mellitus

The intent of this study is to assess the safety of LY2409021 in participants with Type 2
diabetes mellitus taking metformin and sulfonylurea as prescribed by their personal
physician. The study treatment is expected to last 12 months (52 weeks).


Inclusion Criteria:

- Have been treated with a stable dose of metformin for at least 3 months and have been
treated with an optimally effective and stable dose of an sulfonylurea for at least 6
months prior to screening.

- HbA1c value between 7.0% and 10.0%, inclusive.

- Body mass index (BMI) between 20 and 45 kilograms/square meter (kg/m^2), inclusive.

Exclusion Criteria:

- Known type 1 diabetes mellitus.

- More than 1 episode of severe hypoglycemia within 6 months prior to screening.

- Two or more emergency room visits or hospitalizations due to poor glucose control in
the 6 months prior to screening.

- Severe gastrointestinal disease that may significantly impact gastric emptying or
motility or having undergone gastric bypass or gastric banding surgery.

- Previous history or active diagnosis of pancreatitis.

- Positive hepatitis B surface antigen or hepatitis C antibody.

- Clinical signs or symptoms of liver disease, or hepatic aminotransferases
(aminotransferase or alanine aminotransferase) greater than 2.0× upper limit of normal
(ULN) or elevated alkaline phosphatase (greater than ULN) unrelated to bone metabolic
disease.

- Elevated total bilirubin level (greater than ULN), clinically suspicious
signs/symptoms of cirrhosis or history of cirrhosis.

- Current diagnosis, personal history of neuroendocrine tumors, family history of any
type of multiple endocrine neoplasia (MEN), or Von Hippel-Lindau.

- Contraindications for magnetic resonance imaging.
We found this trial at
27
sites
2500 Campus Rd
Honolulu, Hawaii 96822
(808) 956-8111
Univ of Hawaii Honolulu Community College is an integral part of the University of Hawai?i,...
4499
mi
from 43215
Honolulu, HI
Click here to add this to my saved trials
2010 Wilshire Boulevard
Los Angeles, California 90057
213-413-2500
1973
mi
from 43215
Los Angeles, CA
Click here to add this to my saved trials
2128 W Flagler St # 201
Miami, Florida 33144
993
mi
from 43215
Miami, FL
Click here to add this to my saved trials
5330
mi
from 43215
Athens,
Click here to add this to my saved trials
Chattanooga, Tennessee 37403
361
mi
from 43215
Chattanooga, TN
Click here to add this to my saved trials
Chicago, Illinois 60607
275
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
501
mi
from 43215
Columbia, MO
Click here to add this to my saved trials
2081
mi
from 43215
Concord, CA
Click here to add this to my saved trials
Crystal Lake, Illinois 60012
318
mi
from 43215
Crystal Lake, IL
Click here to add this to my saved trials
906
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Dallas, Texas 75251
904
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Des Moines, Iowa 50314
565
mi
from 43215
Des Moines, IA
Click here to add this to my saved trials
Downingtown, Pennsylvania 19335
?
mi
from 43215
Downingtown, PA
Click here to add this to my saved trials
Fresno, California 93720
1986
mi
from 43215
Fresno, CA
Click here to add this to my saved trials
Georgetown, Texas 78626
1045
mi
from 43215
Georgetown, TX
Click here to add this to my saved trials
Honolulu, Hawaii 96814
4501
mi
from 43215
Honolulu, HI
Click here to add this to my saved trials
1508
mi
from 43215
Idaho Falls, ID
Click here to add this to my saved trials
Lake Charles, Louisiana 70601
?
mi
from 43215
Lake Charles, LA
Click here to add this to my saved trials
Las Vegas, Nevada 89102
1756
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
Miami, Florida 33175
996
mi
from 43215
Miami, FL
Click here to add this to my saved trials
San Antonio, Texas 78128
1138
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
San Antonio, Texas 78229
1138
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
Seattle, Washington 98122
2006
mi
from 43215
Seattle, WA
Click here to add this to my saved trials
Springfield, Missouri 65807
585
mi
from 43215
Springfield, MO
Click here to add this to my saved trials
5115 North Armenia Avenue
Tampa, Florida 33603
827
mi
from 43215
Tampa, FL
Click here to add this to my saved trials
Toms River, New Jersey
467
mi
from 43215
Toms River, NJ
Click here to add this to my saved trials
Topeka, Kansas 66606
679
mi
from 43215
Topeka, KS
Click here to add this to my saved trials