A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer

High-risk patients will be identified based on their core-needle biopsy features, PSA levels,
and clinical stage. After obtaining baseline laboratory and clinical values (including an
ECG, PSA, hematologic, and renal and hepatic panels), men will receive oral LDE225 800 mg/day
or observation daily for 4 weeks (±3 days) prior to prostatectomy. Patients will have a
clinical visit and an ECG and laboratory testing will be performed at 2 weeks and then again
at 4 weeks, including a 4-week pre-prostatectomy measurement of PSA and a blood sample to
determine plasma LDE225 levels. Men will undergo radical prostatectomy (with bilateral pelvic
lymphadenectomy as appropriate), at which point two 250-mg biopsies of prostate tissue will
be obtained, frozen and stored for analysis.

Inclusion Criteria:

1. Provide written informed consent prior to any screening procedures.

2. Age 18 years or older.

3. Histologically-documented prostatic adenocarcinoma in ≥2 cores

4. ECOG performance status ≤2

5. Localized prostate cancer with at least one of the following NCCN high-risk features:

- Gleason sum ≥8

- PSA >20 ng/mL

- Clinical stage ≥T3

6. Must be a candidate for radical prostatectomy

7. No evidence of known metastatic disease (M0 or Mx allowed)

8. Adequate bone marrow, liver and renal function as specified below:

- Absolute neutrophil count (ANC) ≥ 1500/µL

- Hemoglobin (Hgb) ≥ 9.0 g/dL

- Platelets ≥100,000/µL

- Serum total bilirubin ≤ 1.5 x ULN (upper limit of normal)

- AST and ALT ≤ 2.5 x ULN

- Plasma creatine phosphokinase (CK) < 1.5 x ULN, if known

- Serum creatinine ≤ 1.5 x ULN [or 24-hour creatinine clearance ≥ 50ml/min]

9. Patient is able to swallow and retain oral medications

Exclusion Criteria:

1. Patients who have had major surgery within 4 weeks of enrollment.

2. Patients with concurrent uncontrolled medical conditions that may interfere with their
participation in the study.

3. Patients unable to take oral drugs (e.g. lack of physical integrity of the upper GI
tract or known malabsorption syndromes).

4. Patients who have previously been treated with LDE225 or other Hh pathway inhibitors

5. Patients who have neuromuscular or muscular disorders (e.g. inflammatory myopathies,
muscular dystrophy, amyotrophic lateral sclerosis and spinal muscular atrophy) or are
on concomitant treatment with drugs that are known to cause rhabdomyolysis (such as
statins and fibrates), and that cannot be discontinued at least 2 weeks prior to
starting LDE225. If it is essential that the patient stays on a statin for
hyperlipidemia, only pravastatin may be used with extra caution. Patients should not
plan to embark on a new strenuous exercise regimen after initiation of study
treatment. (NB: Muscular activities, such as strenuous exercise, that can result in
significant increases in plasma CK levels should be avoided whilst on LDE225
treatment).

6. Patients who have taken part in an experimental drug study within 4 weeks or 5
half-lives (whichever is longer) of initiating treatment with LDE225.

7. Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted
therapy or radiotherapy) concurrently or within 2 weeks of starting LDE225.

8. Patients taking moderate/strong inhibitors or inducers of CYP3A4/5 or drugs
metabolized by CYP2B6 or CYP2C9 that have narrow therapeutic index, and that cannot be
discontinued before starting treatment with LDE225. Medications that are strong
CYP3A4/5 inhibitors should be discontinued for at least 7 days and strong CYP3A/5
inducers for at least 2 weeks prior to starting treatment with LDE225.

9. No concurrent use of statins (except for pravastatin, if absolutely necessary)

10. No concurrent warfarin or Coumadin-derivatives

11. Impaired cardiac function or significant heart disease, including any one of the
following:

- Angina pectoris within 3 months

- Acute myocardial infarction within 3 months

- QTc >450 msec on the screening ECG

- A past medical history of clinically significant ECG abnormalities or a family
history of prolonged QT-interval syndrome

- Other clinically significant heart disease (e.g. heart failure,
uncontrolled/labile hypertension, or history of poor compliance with an
antihypertensive regimen)

12. Patients who are not willing to apply highly effective contraception during the study
and through the duration of LDE225 treatment.

- Male patients must use highly effective (double barrier) methods of contraception
(e.g., spermicidal gel plus condom) for the entire duration of the study, and
continuing using contraception and refrain from fathering a child for 6 months
following the last dose of the study drug. A condom is also required to be used
by vasectomized men as well as during intercourse with a male partner in order to
prevent delivery of the study treatment via seminal fluid. Sexually active males
must be willing to use a condom during intercourse while taking the study drug
and for 6 months after stopping investigational medications and agree not to
father a child during this period.

13. Patients unwilling or unable to comply with the research protocol.