Effect of the LIVESTRONG at the YMCA Exercise Program on Cancer Related Outcomes in Cancer Survivors

The proposed study is a randomized trial evaluating the impact of the 12-week LIVESTRONG
exercise program vs. waitlist control on cancer-related outcomes in 200 cancer survivors.
Participants will undergo baseline testing at Dana-Farber or Yale, including administration
of questionnaires to assess quality of life and the presence of cancer and treatment-related
symptoms, fasting blood draw, and evaluation of body composition (using dual energy X-ray
absorptiometry (DEXA). Participants will then take part in the 12-week LIVESTRONG Program or
will be assigned to a wait-list control group. All measurements will be repeated at
Dana-Farber or Yale after the 12-week exercise program or control period.

Inclusion Criteria:

- Cancer diagnosis excluding non-melanoma skin cancer

- Physically able to exercise

- Able to complete forms and understand instructions in English

- Agrees to be randomly assigned to either exercise or wait-list control group

- Willing and able to attend one of the LIVESTRONG at the YMCA programs for 12 weeks

- Willing and able to complete the baseline and 3-month clinic visits

Exclusion Criteria:

- > 80 years of age

- < 18 years of age

- Recent (past 6 months) stroke/myocardial infarction or congestive heart
failure/documented ejection fraction < 40%

- Plans to undergo a major surgical procedure in the next 6 months

- Presence of dementia or major psychiatric disease that would preclude participation
in a group-based exercise program

- Pregnant women or women intending to become pregnant