Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging



Status:Completed
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:19 - 90
Updated:9/21/2018
Start Date:September 3, 2014
End Date:March 23, 2018

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to measure the changes in cardiac function during a Lexiscan
pharmacologic stress test using cardiac magnetic resonance imaging test.


Inclusion Criteria:

- Myocardial rest/regadenoson stress perfusion PET study within 60 days

- Normal rest LVEF (greater than or equal to 50%)

- No change in symptoms or treatment between the PET and the MRI study

- Willing to consent to the study

- Male or female who is either post-menopausal, surgically sterile, or if has a
childbearing potential, a negative pregnancy test within 2 days prior to the MRI
study.

Exclusion Criteria:

- Renal dysfunction (estimated glomerular filtration rate < 60 mL/min/1.73m2) within 6
months

- Metallic implants, pacemaker, blood vessel clip (contra-indicated for MRI)

- Patient size exceeds MRI bore/table limits: (Max body diameter > 60 cm, weight > 136
kg)

- History of gadolinium contrast allergy or intolerance

- Second or third degree AV block

- Sinus node dysfunction

- Acute myocardial infarction (past 3 months)

- Actively wheezing or with acute asthma or bronchospastic attacks requiring changes in
therapy within the past 30 days

- Patients that have experienced a previous hypersensitivity reaction thought to be
related to regadenoson
We found this trial at
1
site
Saint Luke's Health System
Kansas City, Missouri 64111
Principal Investigator: Joseph Soltys, PhD
Phone: 816-531-2842
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mi
from
Kansas City, MO
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