Early Intervention and Prevention of Non-Alcoholic Fatty Liver Disease in Adolescents
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 11 - 17 |
| Updated: | 10/13/2018 |
| Start Date: | April 2014 |
| End Date: | October 2017 |
This research study intends to learn about whether early intervention can help to prevent
non-alcoholic fatty liver disease (NAFLD) in adolescents. Potentially eligible adolescents
who are seen at the University of Wisconsin (UW) Pediatric Fitness Clinic will be asked to
join the study. Patients who agree to participate in the study will be randomized into either
the intervention group or the control group. The intervention group will follow a
low-fructose diet. In addition, participants will be asked to return to the clinic for 4
follow-up visits during a 6-month interval.
non-alcoholic fatty liver disease (NAFLD) in adolescents. Potentially eligible adolescents
who are seen at the University of Wisconsin (UW) Pediatric Fitness Clinic will be asked to
join the study. Patients who agree to participate in the study will be randomized into either
the intervention group or the control group. The intervention group will follow a
low-fructose diet. In addition, participants will be asked to return to the clinic for 4
follow-up visits during a 6-month interval.
This will be a prospective, randomized, controlled trial for obese adolescents. Sixty obese
youth (male and female), age 11-17 years with BMI >95 %tile for age and sex and one
parent/guardian will be recruited for inclusion into the study at an initial pediatric
fitness clinic visit. Consented subjects will be stratified by gender and ethnicity and
randomized into low fructose or standard weight loss dietary intervention groups.
youth (male and female), age 11-17 years with BMI >95 %tile for age and sex and one
parent/guardian will be recruited for inclusion into the study at an initial pediatric
fitness clinic visit. Consented subjects will be stratified by gender and ethnicity and
randomized into low fructose or standard weight loss dietary intervention groups.
Inclusion Criteria:
- 11-17 years of age
- BMI >95%tile for age and sex
- Being seen for an initial clinic visit at the UW Pediatric Fitness Clinic
- Parent willing to participate in study
Exclusion Criteria:
- History of chronic disease that effects hepatic or renal function including: Type 1 or
Type 2 diabetes mellitus, known liver disease or other chronic illness.
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