Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Blood Cancer, Blood Cancer, Blood Cancer, Blood Cancer, Hematology, Hematology, Hematology, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 20 - 60 |
| Updated: | 2/7/2015 |
| Start Date: | June 2014 |
| End Date: | March 2015 |
| Contact: | Amanda Cashen, M.D. |
| Email: | acashen@dom.wustl.edu |
| Phone: | 314-454-8491 |
Early Post-transplant Contrast-enhanced Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Contrast-enhanced abdominal CT will be performed 1-2 weeks after allogeneic stem cell
transplant, and radiographic evidence of mucosal inflammation will be correlated with the
subsequent development of acute graft versus host disease. The primary endpoint is the
feasibility and safety of contrast-enhanced abdominal CT in the early post-transplant
period, as defined by the risk of contrast-related nephropathy or allergic reaction.
transplant, and radiographic evidence of mucosal inflammation will be correlated with the
subsequent development of acute graft versus host disease. The primary endpoint is the
feasibility and safety of contrast-enhanced abdominal CT in the early post-transplant
period, as defined by the risk of contrast-related nephropathy or allergic reaction.
Inclusion Criteria:
- Biopsy-proven diagnosis of a hematologic malignancy
- Scheduled to undergo allogeneic SCT from a matched sibling donor or an unrelated
donor who is 10/10 or 9/10 HLA match. Transplant eligibility is per standard and
institutional criteria.
- Age 18-60 years
- Willing and able to provide informed consent
Exclusion Criteria:
- Documented or reported contrast allergy
- Estimated glomerular filtration rate (GFR) < 60
- Deemed too sick by clinician to leave the floor for imaging
- "Nothing-per-mouth" status for other clinical reasons
Inclusion of Women and Minorities
-Both men and women and members of all races and ethnic groups are eligible for this
trial.
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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